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慈濟大學 公共衛生學系碩士班 謝佳容所指導 余葦琳的 補充維生素B12對素食者血中同型半胱氨酸濃度之影響 (2018),提出How to pronounce rhy關鍵因素是什麼,來自於維生素B12、素食者、同型半胱氨酸、補充維生素、隨機臨床試驗。

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補充維生素B12對素食者血中同型半胱氨酸濃度之影響

為了解決How to pronounce rhy的問題,作者余葦琳 這樣論述:

BackgroundVegetarian diet is associated with various beneficial outcomes on health. However, potential drawbacks of vegetarian diet and possible solutions remain uncertain. Vegetarian diet is potentially deficient in Vitamin B12, since foods of animal origins are the main sources of it. Vitamin B12

serves as an important co-factor in Homocysteine (Hcy) metabolism.ObjectivesThe objectives of this study are: 1) To evaluate the Vitamin B12 and Hcy status among vegetarians; 2) To assess the efficacy of oral supplementation with Vitamin B12 on reducing the plasma Hcy levels among vegetarians.Mater

ials and methodsA prospective cohort study of Tzu Chi Health Study (TCHS) was conducted at Buddhist Dalin Tzu Chi Hospital. A total of 6002 adults aged 18 to 87 years old who came to hospital for a health examination were recruited during October 2007 to December 2009. Blood samples for evaluation o

f Hcy and Vitamin B12 levels were taken in the first 1528 participants. Sixty-five vegetarians with hyper Hcy (plasma Hcy >12 μmol/L) participated the further intervention study. Participants were randomly assigned in a 1:1 ratio into interventional group (n=33) and control group (n=32). Baseline de

mographic status of the participants was assessed by questionnaires, general physical examination and laboratory tests. Participants in the intervention group received an oral tablet of 500μg Vitamin B12 daily, while the control group received a placebo tablet daily, with the duration of interventio

n for 6 months. Repeated measurements of plasma Hcy and Vitamin B12 were taken at 0, 3, 6, 9 and 12 months.ResultsOut of the 1528 participants 66.6% are non-vegetarians and 33.4% are vegetarians. Vegetarians significantly have higher Hcy, lower Vitamin B12 and higher folic acid level. In the subsequ

ent randomized controlled trial study, the reduction of plasma Hcy level is significant starting from the 3rd month after the supplementation (β±SE= -6.23±1.50, p