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Strategic Air Command

為了解決Introduction of air 的問題，作者Wright, Kevin 這樣論述：

Strategic Air Command (SAC) was the pre-eminent military actor in US nuclear policy from the start to the end of the Cold War. Illustrated with over 170 photographs, this book provides an examination of SAC, covering its aircraft, operations, people and locations. It will look at the introduction

of new aircraft and early ballistic missiles with Curtis LeMay as Commander of SAC up to Cuban missile crisis. Post Cuba, the B-52 and KC-135 dominated force and second generation missiles will be covered. Then, the late 1960s/early1970s will see the pressures of the bomber force involvement in Vie

tnam, and the introduction of the FB-111A. Finally, comes the introduction of the B-1 and how, in 1980s, SAC readiness reached a peak. Interweaved through that account will be material covering new equipment, the importance of SAC strategic reconnaissance aircraft (the RB-29, RB-45, RB-50, U-2/TR-1,

SR-71, B-47 and RC-135), SAC readiness programmes (ORI), and its command and control mechanisms - especially EC-135s and E-4s and PACCS.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Introduction of air 的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Plant a Tree & Re-Tree the World: Retree the World

為了解決Introduction of air 的問題，作者Raskin, Ben 這樣論述：

There has never been a better time to plant a tree! From their invaluable role in fighting climate change and cleaning the air of our cities, to the huge mental health benefits being around their leafy presence can bring, trees are at the very centre of both our urban and rural ecosystems. Writte

n by Ben Raskin, head of horticulture at the Soil Association, and supported by Friends of the Earth UK, this earthy call-to-action teaches the practical how-tos alongside the most interesting insights to appreciate about the significance of magnificent trees. As movements to rewild the world around

us gain pace, tree planting is being recognised as an empowering, practical and surprisingly simple action that each and every one of us can do in our backyard, park, local community, school, town, or city. Sections in this book include: Trees and the World - This sectioncelebrates just how vital t

rees are, from how they help regulate the climate and absorb dangerous methane and nitrous oxide, to how they enrich soil, support wildlife, and keep our city air clean, as well as the threats they face from climate change. Growing Your Own Tree - Tips on growing saplings from seed, cuttings, or gra

fting, plus guidance on care and maintenance, from weeding and mulching to when to prune and pollard. Tree Identification Guide - A guide to the top40 of our favourite trees, appreciated for their fruit and nuts, their ornamental value, and the role they play in supporting wildlife, including a neat

introduction to how to recognise trees by their leaf shape, flowers, seeds, and fruit. Trees and Happiness - Research has revealed that trees are effective at reducing stress levels and improving our mental well-being, and this section digs into exactly how this happens. Whether you’re a keen gard

ener, an avid environmental activist, or simply want to learn more about these beautiful and powerful organisms, this must-read book illustrated by popularscreen-printerRosanna Morris sends the powerful message that we can plant a tree & retree the world!

植基於5G多型態網路環境下使用區塊鏈技術進行身份驗證之研究

為了解決Introduction of air 的問題，作者高一陳 這樣論述：

5G的巨量通訊和低延遲通訊兩個特性，對於企業加速數位轉型時的應用非常重要，尤其是現在已經進入工業4.0時代，網路通訊品質格外重要，結合5G通訊特性及Wi-Fi 6優點的多型態網路，儼然已成為網路新時代的架構，惟本國目前的5G架構因為成本建置考量，尚屬於NSA架構，或許未來硬體更成熟，成本較低時，或許也會採用SA。使用區塊鏈3.0的技術主要是它針對物聯網有提供相當完整及方便的函數庫，而且區塊鏈3.0的特性是不用挖礦，沒有礦工角色，而且越多人使用，驗證速度越快，與區塊鏈1.0或2.0技術不一樣。將傳統的紙本證件，使用區塊鏈3.0技術，將它轉成電子化資料，只要儲存認證完成的交易代碼，就能夠透過此代

碼找到相關原始資料，傳統書面證書或者紙本資料，轉為具有區塊鏈技術架構的數位證書，已經是未來的趨勢。利用IOTA技術提供5G驗證與Wi-Fi 6驗證結合，透過Python 跟C# .Net電腦語言，實作出應用區塊鏈3.0技術來驗證物聯網設備在多型態網路的環境下，可以達到驗證效果，這是本研究的主軸，跳脫傳統的驗證方式，且更具安全性的驗證。