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The Unstoppable Sales Machine: How to Connect, Convert, and Close New Customers

為了解決Significant increase的問題，作者Casemore, Shawn 這樣論述：

You’re in big trouble if you rely on having ＂feet on the street＂ to generate new sales. Selling in today’s economy has forever changed. Buyers today are more challenging to reach and offer less of their time to anyone in sales. So it’s time to rethink how we generate sales to create a sustainable

model that produces consistent results.This book addresses the shifts sales professionals, and their organizations need to make in introducing modern sales strategies. It provides insights and proven strategies for business owners, sales executives, leaders, and professionals -- anyone who desires

to create a rapid and sustained increase in their sales without investing significant time or money.In a comprehensive review of the author’s work with global companies, Casemore introduces a model for ＂Unstoppable Selling＂ -- capturing the strategies and tactics of how top-performing companies have

continued to sell more each year, all while increasing the predictability of their sales growth.This book contains powerful models, tools, and resources, including the Hybrid Sales Funnel, Rocket Fuel Referral Process, and the Market Maximizer. In addition, the book demonstrates how you can quickly

establish your Unstoppable Sales Machine regardless of the size or sector of your company.Introducing your own unstoppable sales machine will not require you to hire a bunch of experts or more employees. This book accepts you where you are and then walks you through the steps to quickly introduce a

nd launch your very own machine. You’ll find all the advice, guidance, case studies, and worksheets in this one convenient book ready for you to implement. If you intend to scale your business or want more freedom from the daily rollercoaster of your current sales strategy, this is the book for you.

Selling is a noble profession and the heart and soul of every business -- Yet the continued evolution of today’s customers, how they engage, select, and buy products and services, requires we rethink how we approach selling. In this book, Casemore shows you how to become an expert at sales while hav

ing the freedom and comfort of knowing that your machine will never let you down.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Significant increase的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Healthcare Delivery in the U.S.A.: An Introduction

為了解決Significant increase的問題，作者Schulte Dba, Margaret 這樣論述：

With the same clarity that made the previous editions bestsellers, Healthcare Delivery in the U.S.A.: An Introduction, Third Edition provides readers with the understanding required to navigate the healthcare provider field. In the intervening 8 years since the 2nd Edition was published, there ha

ve been significant developments in the healthcare delivery systems, including COVID-19, global health issues, and the evolution of the Affordable Care Act and other financing mechanisms. Brilliantly simple, yet comprehensive, this updated edition includes updated case studies and describes the new

organizational structures being driven by current market conditions. Focusing on healthcare management, the book addresses the range of topics critical to understanding the U.S. healthcare system, including the quality of care movement, delivering care during a pandemic, recent finance reform, new t

echnologies, cyber security, and the recent increase in merger and acquisition activity. Dr. Schulte walks readers through the history of the development of U.S. healthcare delivery. She describes the various venues of care delivery as well as the different elements of the financing system. Offering

a glimpse into the global market and medical tourism, the text includes coverage of legal and regulatory issues, workforce, and the drivers and barriers that are shaping healthcare delivery around the world. Painting a clear and up-to-date picture, this quick-and-easy read provides you with the und

erstanding of the terminology, structures, roles, relationships, and nuances needed to interact effectively and efficiently with anyone in the healthcare provider field.

八週核心肌群訓練對國小田徑選手速度、爆發力與敏捷性之影響

為了解決Significant increase的問題，作者駱翠環 這樣論述：

　　本研究探討八週核心肌群訓練對國小田徑選手速度、爆發力與敏捷性之影響，以屏東縣九如國小田徑隊年齡介於11歲至12歲，共20名學童為研究對象，分成實驗組10名，控制組10名。除研究對象原訂的課表訓練之外，實驗期間內實驗組八週需額外接受每週3次核心肌群訓練、每次約40分鐘。　　核心訓練課程包含捲腹運動、背部伸展式、棒式運動、側面棒式運動、橋式運動、雙腳跳階、跪姿式伏地挺身、跳繩、跑上走下(30階)，訓練前後進行測試，經由單因子共變數分析，比較訓練組和控制組在介入前、後是否有顯著的差異。八週訓練後發現，對速度有顯著的提升(60公尺成績，實驗組10.00.77秒vs.控制組11.40.17秒，

p＜.05)、(100公尺成績，實驗組17.60.26秒vs.控制組18.50.26秒，p＜.05)。對爆發力有顯著的提升(立定跳遠成績，實驗組159.53.28公分vs.控制組145.73.28公尺，p＜.05)。對敏捷性有顯著的提升(反覆測併步成績，實驗組16.00.50秒vs.控制組16.30.50秒，p＜.05)、(十公尺折返跑成績，實驗組11.20.25秒vs.控制組12.00.24秒，p＜.05)。研究結果指出透過八週核心肌群訓練對田徑國小選手速度、爆發力、敏捷性具有提昇的效果。