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driving classes near的問題,我們搜遍了碩博士論文和台灣出版的書籍,推薦Furuness, Bryan (EDT)寫的 My Name Was Never Frankenstein: And Other Classic Adventure Tales Remixed 和Furuness, Bryan (EDT)的 My Name Was Never Frankenstein: And Other Classic Adventure Tales Remixed都 可以從中找到所需的評價。

這兩本書分別來自 和所出版 。

長庚大學 奈米工程及設計碩士學位學程 周煌程、杨杰圣所指導 梁文顏的 低功耗高性能電流式感測放大器設計 (2020),提出driving classes near關鍵因素是什麼,來自於電流式電路、感測放大器。

而第二篇論文臺北醫學大學 新藥研發產業博士學位學程 黃偉展、許凱程所指導 曾惠如的 開發小分子藥物用於治療中樞神經系統疾病 (2020),提出因為有 中樞神經系統疾病、阿滋海默氏症、神經膠質母細胞瘤、多發性硬化症的重點而找出了 driving classes near的解答。

接下來讓我們看這些論文和書籍都說些什麼吧:

除了driving classes near,大家也想知道這些:

My Name Was Never Frankenstein: And Other Classic Adventure Tales Remixed

為了解決driving classes near的問題,作者Furuness, Bryan (EDT) 這樣論述:

You know the names and the stories, but you've never seen them like this before My Name Was Never Frankenstein: And Other Classic Adventure Tales Reanimated brings your favorite characters back to life in new and exciting escapades. In this inventive collection, a stellar cast of writers uses class

ic adventure tales as a launch pad for an eclectic mix of prequels, alternate universes, spin-offs, and total reboots. Imagine Ahab is shipwrecked on an island of cannibals, or Mr. Hyde tells his side of the story, or the scarecrow from Oz struggles with the mystery of his existence. By turns wry an

d haunting, My Name Was Never Frankenstein upends old territory and classic characters to reclaim them for a new generation. Rachel Brittain is an alumna of Vanderbilt University, but currently lives and writes in Arkansas. Her short film, "The Delivery Girl," has been screened at film festivals i

n Los Angeles and New York, and her novelette, "End of the World Talk Show," is forthcoming in Hyperion and Theia.Margaret Patton Chapman is the author of the novella Bell and Bargain from Rose Metal Press. Her short fiction has appeared in Diagram, The Collagist, and Prick of the Spindle, among oth

ers. She lives in Durham, NC and teaches at Elon University.Michael Czyzniejewski’s most recent collection of stories is I Will Love You For the Rest of My Life: Breakup Stories (Curbside Splendor, 2015). He is an associate professor of English at Missouri State University, where he serves as Editor

-in-Chief of Moon City Review and Managing and Literary Editor for Moon City Press.Tony Eprile’s novel, The Persistence of Memory, was a New York Times Notable Book of the Year and won the Koret Jewish Book prize. His stories--several of which are literary homages--have appeared in Ploughshares, Agn

i, Story Quarterly, GlimmerTrain, Post Road, and elsewhere. He teaches fiction in Lesley University’s low-residency graduate program.Kelcey Parker Ervick spent many summers visiting her grandparents in Barnegat, NJ, gazing out at Old Barney, the distinctive red and white lighthouse across the bay. S

ome of the details and journal entries in her story are taken from Women Who Kept the Lights: An Illustrated History of Female Lighthouse Keepers by Mary Louise Clifford and J. Candace Clifford, which she found at her grandparents’ house and "borrowed" with a promise to write a story one day. She li

ves in South Bend, Indiana, an hour away from Michigan City Lighthouse, where Harriet Colfax kept the light for 43 years. She is pretty sure women lighthouse keepers are the most adventurous of us all.Kathleen Founds has worked at a nursing home, a phone bank, a South Texas middle school, and a Midw

estern technical college specializing in truck-driving certificates. She got her undergraduate degree at Stanford and her MFA at Syracuse. She teaches social justice themed English classes at Cabrillo College in Watsonville, CA, and writes while her toddler is napping. Her work has been published in

The Sun, Good Housekeeping, The New Yorker Online, McSweeney’s Internet Tendency, Salon and Booth Journal. Her novel-in-stories, When Mystical Creatures Attack! won the 2014 University of Iowa Press John Simmons Short Fiction Award and was named a New York Times Notable Book.Bryan Furunessis the a

uthor of The Lost Episodes of Revie Bryson, a novel. With Michael Martone, he co-edited the anthology, Winesburg, Indiana. His stories can be found in New Stories from the Midwest and Best American Nonrequired Reading, and elsewhere. He lives in Indianapolis, where he teaches at Butler University.Mo

lly Gutman is an MFA candidate in fiction at the University of Nevada, Reno. You can find her stories and poems in Black Warrior Review, Mid-American Review, Hayden’s Ferry review Online, Psychopomp Magazine, The Pinch, and elsewhere.Pam Houston is the author of two collections of linked short stori

es, Cowboys Are My Weakness and Waltzing the Cat. Her stories have been selected for the 1999 volumes of Best American Short Stories, The O. Henry Awards, The Pushcart Prize, and she is a regular contributor to O, the Oprah Magazine, The New York Times, Bark, More, and many other periodicals. A coll

ection of autobiographical essays, A Little More About Me (W.W. Norton), was published in 1999, and a novel, Sight Hound (W.W. Norton) in 2005. Houston has edited a collection of fiction, nonfiction and poetry for Ecco Press called Women on Hunting, and written the text for a book of photographs cal

led Men Before Ten A.M. (Beyond Words, 1996). Her novel, Contents May Have Shifted, was released in 2012 by W.W. Norton.Kirsty Logan is the author of short story collection The Rental Heart and Other Fairytales, awarded the Polari First Book Prize and the Saboteur Award for Best Short Story Collecti

on, and debut novel The Gracekeepers, awarded a Lambda Literary Award. Her most recent book, A Portable Shelter, is a collection of linked short stories inspired by Scottish folktales and was published in a limited edition with custom woodblock illustrations. Her next novel, The Gloaming, is out in

May 2018. She is currently working on a collection of short horror stories, a TV pilot script, and a musical collaboration project.Gregory Maguire is the New York Times bestselling author of Confessions of an Ugly Stepsister; Lost; Mirror Mirror; and the Wicked Years, a series that includes Wicked,

Son of a Witch, A Lion Among Men, and Out of Oz. Now a beloved classic, Wicked is the basis for a blockbuster Tony Award-winning Broadway musical. Maguire has lectured on art, literature, and culture both at home and abroad. He lives with his family near Boston, Massachusetts.Corey Mesler has been

published in numerous anthologies and journals including Poetry, Gargoyle, Five Points, Good Poems American Places, and Esquire/Narrative. He has published 9 novels, 4 short story collections, and 5 full-length poetry collections, and a dozen chapbooks. His novel, Memphis Movie, attracted kind words

from Ann Beattie, Peter Coyote, and William Hjorstberg, among others. He’s been nominated for the Pushcart many times, and 2 of his poems were chosen for Garrison Keillor’s Writer’s Almanac. With his wife he runs a 142 year-old bookstore in Memphis. He can be found at https: //coreymesler.wordpress

.com.Michael Poore is the author of the novels Reincarnation Blues (Del Rey, 2017) and Up Jumps the Devil (Ecco, 2012). His short work has appeared in numerous magazines and anthologies, including The Year’s Best Science Fiction and The Best American Nonrequired Reading 2012. He lives with his wife,

poet Janine Harrison, and daughter Jianna, in Highland, IN.Edward Porter’s short fiction has appeared in Glimmer Train, The Hudson Review, The Gettysburg Review, Colorado Review, Booth, Barrelhouse, Catamaran, Best New American Voices, and elsewhere. He holds an MFA from Warren Wilson College and a

PhD from the University of Houston. He has been a Madison, Macdowell, and Stegner Fellow, and taught creative writing at Milllsaps College. Currently he is a Jones Lecturer in Fiction at Stanford University.

低功耗高性能電流式感測放大器設計

為了解決driving classes near的問題,作者梁文顏 這樣論述:

Table of ContentsRecommendation Letters from Thesis AdvisorsThesis/Dissertation Oral Defense Committee CertificationPreface iiiAbstract ivTable of Contents vList of Figures viiList of Tables xiChapter 1 Introduction 11.1 Memory and Processors 21.2 Sense Amplifiers 31.3 Technology Trends 41.4 Circui

t Trends 51.5 Other Trends 61.6 SRAM Trends 71.7 Associated Challenges 9Chapter 2 A Circuits Survey 102.1 The Two Broad Classes 102.2 Voltage Sensing 122.3 Current Sensing 162.4 Others 20Chapter 3 Development of a Three-Transistor I–V Converter 223.1 Low Drop-Out Voltage Regulator as a I–V Converter

233.2 I–V Converter as a Current Sense Amplifier 253.3 Simplifying the I–V Converter 253.4 Proof of Concept 273.5 Quest for a Better Error Amplifier 293.6 Revisiting the Proof of Concept 31Chapter 4 Implementation of a Current Sense Amplifier 344.1 Sense Amplifier Shut-Down 344.2 Static Power Reduc

tion 364.3 Pulsed Word-Line Operation 374.4 Bit-Line Capacitance—Effect on Delay 394.5 Bias Variation 414.6 Relevant Concerns 43Chapter 5 Conclusion 445.1 Simulation Results 445.2 Considerations for Long Bit-Lines 465.3 Measurements 475.4 Derivative Circuits 495.5 Derivative Use 525.6 Summary 555.7

Final Thoughts 55References 56Appendices 83List of FiguresFigure 1.1 Die micrograph from [Singh et al., 2018] 2Figure 1.2 Layout from [Takemoto et al., 2020] 2Figure 1.3 Package from [Poulton et al., 2019] 4Figure 1.4 Wearable for happiness index from [Yano et al., 2015] 6Figure 1.5 Test chip from [

Song et al., 2017] 7Figure 2.1 Left–right: nMOS common-source, -gate and -drain amplifier configurations 10Figure 2.2 Left–right: pMOS common-drain, -gate and -source amplifier configurations 11Figure 2.3 Bi-stable constructed of two inverters 11Figure 2.4 Regenerative latch transient simulation out

put 11Figure 2.5 nMOS differential pair 12Figure 2.6 nMOS–input pair differential amplifier 13Figure 2.7 Clocked latch with isolation 14Figure 2.8 Current-controlled latch 15Figure 2.9 Left–right: Resistor and nMOS approximates 16Figure 2.10 Left–right: Resistor and pMOS approximates 16Figure 2.11 n

-p-n common-base amplifier 17Figure 2.12 Partial schematic from [Yeo and Rofail, 1995] 17Figure 2.13 Left–right: nMOS and pMOS current mirrors 18Figure 2.14 Current sense amplifier from [Ishibashi et al., 1995] 18Figure 2.15 Current sense amplifier from [Seno et al., 1993] 19Figure 2.16 Current conv

eyor from [Seevinck et al., 1991] 19Figure 2.17 pMOS-neutralised nMOS differential pair 20Figure 2.18 Λ-type negative resistance from [Wu and Lai, 1979] 21Figure 2.19 I D -V D characteristic of the Λ-type negative resistance 21Figure 3.1 Three-transistor I–V converter 22Figure 3.2 Simplified low dro

p-out voltage regulator 23Figure 3.3 Low drop-out voltage regulator configured as a I–V converter 24Figure 3.4 Low drop-out voltage regulator as a current sense amplifier 25Figure 3.5 Reference-free I–V converter 26Figure 3.6 Logic inverters as positive-gain amplifier 26Figure 3.7 Proof of concept d

esign 27Figure 3.8 Proof of concept design transient simulation output 28Figure 3.9 Typical and unintended input(s) of the logic inverter 29Figure 3.10 Normalised absolute gain plot for each inverter input 30Figure 3.11 Connections made for the absolute gain plot 30Figure 3.12 Bias generator for the

absolute gain plot 31Figure 3.13 Error amplifier replacement in the proof of concept design 31Figure 3.14 Three-transistor I–V converter 32Figure 3.15 Corresponding bias generator of Figure 3.14 32Figure 3.16 Simulation circuit for verifying the improved error amplifier 33Figure 3.17 Demonstration

of the three-transistor I–V converter as a current sense amplifier 33Figure 4.1 Actions to achieve desired node characteristics during shut-down 34Figure 4.2 Figure 3.14 modified for shut-down 35Figure 4.3 Corresponding bias generator of Figure 4.2 35Figure 4.4 Shared use of bias generator 36Figure

4.5 Pseudo-differential version of Figure 4.4 37Figure 4.6 Pseudo-differential configuration of Figure 3.14 37Figure 4.7 Pulsed read of a ZERO 38Figure 4.8 Pulsed read of a ONE 38Figure 4.9 Differential development across dynamic bit-lines and csa outputs 39Figure 4.10 Delay behaviour with capacitiv

e bit-line loading 40Figure 4.11 Normalised csa bias current variation with supply voltage 41Figure 4.12 Normalised csa bias current variation with temperature 42Figure 4.13 Mismatch view of Figure 3.14 43Figure 5.1 Test set-up (external trigger connection not drawn) 47Figure 5.2 Oscillogram demonst

rating circuit functionality at VDD = 2.55V 47Figure 5.3 Test set-up photograph 48Figure 5.4 Left–right: Three-transistor I–V converter and its complement 49Figure 5.5 Transfer characteristics of the circuits in Figure 5.4 49Figure 5.6 Four-transistor I–V converter 50Figure 5.7 Corresponding bias ge

nerator of Figure 5.6 50Figure 5.8 Impact of sizing on AC performance 51Figure 5.9 Left–right: V SS -, V DD -referenced and floating optical receiver front ends 52Figure 5.10 Transfer characteristic of floating I–V converter 53Figure 5.11 High output resistance eases filter realisation 53Figure 5.12

Three-transistor I–V converter operating as an open-drain receiver 54Figure A.1 inv symbol 84Figure A.2 Alternate inv symbol 84Figure A.3 inv transistor-level schematic 84Figure A.4 inv4 symbol 85Figure A.5 inv4 transistor-level schematic 85Figure A.6 inv16 symbol 86Figure A.7 inv16 transistor-leve

l schematic 86Figure A.8 nand2 symbol 87Figure A.9 nand2 transistor-level schematic 87Figure A.10 nand2b symbol 88Figure A.11 nand2b gate-level schematic 88Figure A.12 nor2 symbol 89Figure A.13 nor2 transistor-level schematic 89Figure A.14 nor2b symbol 90Figure A.15 nor2b gate-level schematic 90Figu

re A.16 or2 symbol 91Figure A.17 or2 gate-level schematic 91Figure A.18 tinv symbol 92Figure A.19 tinv transistor-level schematic 92Figure A.20 dlat symbol 93Figure A.21 dlat gate-level schematic 93Figure A.22 dlatr symbol 94Figure A.23 dlatr gate-level schematic 94Figure A.24 dlats symbol 95Figure

A.25 dlats gate-level schematic 95Figure A.26 tie0 symbol 96Figure A.27 tie0 transistor-level schematic 96Figure A.28 tie1 symbol 97Figure A.29 tie1 transistor-level schematic 97Figure B.1 bit0 symbol 99Figure B.2 bit0 transistor-level schematic 99Figure B.3 bit1 symbol 100Figure B.4 bit1 transistor

-level schematic 100Figure B.5 blrc symbol 101Figure B.6 blrc cell-level schematic 101Figure B.7 pre symbol 102Figure B.8 pre transistor-level schematic 102Figure B.9 rblrc symbol 103Figure B.10 rblrc cell-level schematic 103Figure B.11 wr symbol 104Figure B.12 wr transistor-level schematic 105Figur

e B.13 anand2 symbol 106Figure B.14 Alternate anand2 symbol 106Figure B.15 anand2 transistor-level schematic 107Figure B.16 ckgen symbol 108Figure B.17 ckgen gate-level schematic 108Figure B.18 peri symbol 109Figure B.19 peri cell-level schematic 110Figure B.20 csa symbol 111Figure B.21 csa transist

or-level schematic 111Figure B.22 kobl symbol 112Figure B.23 Alternate kobl symbol 112Figure B.24 kobl transistor-level schematic 113Figure B.25 kobs symbol 114Figure B.26 kobs transistor-level schematic 114Figure C.1 sram1 symbol 116Figure C.2 sram1 block-level schematic 117Figure C.3 sram2 symbol

118Figure C.4 sram2 block-level schematic 119Figure C.5 sram3 symbol 120Figure C.6 sram3 block-level schematic 121Figure D.1 ainvl symbol 123Figure D.2 ainvl transistor-level schematic 123Figure D.3 ainvs symbol 124Figure D.4 Alternate ainvs symbol 124Figure D.5 ainvs transistor-level schematic 124F

igure D.6 cut symbol 125Figure D.7 cut cell-level schematic 126Figure D.8 inAmp symbol 127Figure D.9 inAmp cell-level schematic 127Figure D.10 CD4007 symbol 128Figure D.11 CD4007 transistor-level schematic 128Figure D.12 LF356 symbol 129Figure D.13 LF356 cell-level schematic 129Figure D.14 TL431 sym

bol 130Figure D.15 TL431 cell-level schematic 130Figure D.16 tialp symbol 131Figure D.17 tialp transistor-level schematic 131Figure D.18 tiasd symbol 132Figure D.19 tiasd transistor-level schematic 132Figure D.20 tiasn symbol 133Figure D.21 tiasn transistor-level schematic 133Figure D.22 tiasp symbo

l 134Figure D.23 tiasp transistor-level schematic 134Figure E.1 nfet and equivalent nMOS symbol 135Figure E.2 pfet and equivalent pMOS symbol 136Figure E.3 Circuit for estimating per-bit junction capacitance 137Figure E.4 Simulation output for estimating per-bit junction capacitance 138Figure E.5 Ci

rcuit for estimating per-bit bit-line leakage current 138Figure E.6 ID-VD characteristics 139Figure E.7 ID-VG characteristics 140Figure E.8 anand2 transistor-level schematic 141Figure E.9 Test board functional blocks 144Figure E.10 Test board block-level schematic 145Figure E.11 Signal source connec

ted to abbreviated input network 148Figure E.12 General form of a typical instrumentation amplifier 150Figure E.13 Inverting integrator section of test board 154List of TablesTable 1.1 Semiconductor memory hierarchy 1Table 5.1 Column height h = 512b 44Table 5.2 Column height h = 1Kb 44Table 5.3 Colu

mn height h = 2Kb 44Table 5.4 Summarised measurement results 48Table A.1 List of standard cells 83Table A.2 inv truth table 84Table A.3 inv4 truth table 85Table A.4 inv16 truth table 86Table A.5 nand2 truth table 87Table A.6 nand2b truth table 88Table A.7 nor2 truth table 89Table A.8 nor2b truth tab

le 90Table A.9 or2 truth table 91Table A.10 tinv truth table 92Table A.11 dlat truth table 93Table A.12 dlatr truth table 94Table A.13 dlats truth table 95Table A.14 tie0 truth table 96Table A.15 tie1 truth table 97Table B.1 List of custom cells 98Table B.2 pre truth table 102Table B.3 wr truth tabl

e 104Table C.1 SRAM cells and read path configurations 115Table D.1 List of other cells 122Table E.1 Transistor performance 140Table E.2 Primary bill of materials 146Table E.3 Additional hardware 147Table E.4 List of instruments 155Table F.1 List of abbreviations 158Table F.2 List of symbols 159Tabl

e F.3 List of AC quantities 160Table F.4 List of DC quantities 161Table F.5 List of partial-swing signals 162Table F.6 List of rail–rail signals 162Table F.7 List of instance names 163

My Name Was Never Frankenstein: And Other Classic Adventure Tales Remixed

為了解決driving classes near的問題,作者Furuness, Bryan (EDT) 這樣論述:

You know the names and the stories, but you've never seen them like this before My Name Was Never Frankenstein: And Other Classic Adventure Tales Reanimated brings your favorite characters back to life in new and exciting escapades. In this inventive collection, a stellar cast of writers uses class

ic adventure tales as a launch pad for an eclectic mix of prequels, alternate universes, spin-offs, and total reboots. Imagine Ahab is shipwrecked on an island of cannibals, or Mr. Hyde tells his side of the story, or the scarecrow from Oz struggles with the mystery of his existence. By turns wry an

d haunting, My Name Was Never Frankenstein upends old territory and classic characters to reclaim them for a new generation. Rachel Brittain is an alumna of Vanderbilt University, but currently lives and writes in Arkansas. Her short film, "The Delivery Girl," has been screened at film festivals i

n Los Angeles and New York, and her novelette, "End of the World Talk Show," is forthcoming in Hyperion and Theia.Margaret Patton Chapman is the author of the novella Bell and Bargain from Rose Metal Press. Her short fiction has appeared in Diagram, The Collagist, and Prick of the Spindle, among oth

ers. She lives in Durham, NC and teaches at Elon University.Michael Czyzniejewski’s most recent collection of stories is I Will Love You For the Rest of My Life: Breakup Stories (Curbside Splendor, 2015). He is an associate professor of English at Missouri State University, where he serves as Editor

-in-Chief of Moon City Review and Managing and Literary Editor for Moon City Press.Tony Eprile’s novel, The Persistence of Memory, was a New York Times Notable Book of the Year and won the Koret Jewish Book prize. His stories--several of which are literary homages--have appeared in Ploughshares, Agn

i, Story Quarterly, GlimmerTrain, Post Road, and elsewhere. He teaches fiction in Lesley University’s low-residency graduate program.Kelcey Parker Ervick spent many summers visiting her grandparents in Barnegat, NJ, gazing out at Old Barney, the distinctive red and white lighthouse across the bay. S

ome of the details and journal entries in her story are taken from Women Who Kept the Lights: An Illustrated History of Female Lighthouse Keepers by Mary Louise Clifford and J. Candace Clifford, which she found at her grandparents’ house and "borrowed" with a promise to write a story one day. She li

ves in South Bend, Indiana, an hour away from Michigan City Lighthouse, where Harriet Colfax kept the light for 43 years. She is pretty sure women lighthouse keepers are the most adventurous of us all.Kathleen Founds has worked at a nursing home, a phone bank, a South Texas middle school, and a Midw

estern technical college specializing in truck-driving certificates. She got her undergraduate degree at Stanford and her MFA at Syracuse. She teaches social justice themed English classes at Cabrillo College in Watsonville, CA, and writes while her toddler is napping. Her work has been published in

The Sun, Good Housekeeping, The New Yorker Online, McSweeney’s Internet Tendency, Salon and Booth Journal. Her novel-in-stories, When Mystical Creatures Attack! won the 2014 University of Iowa Press John Simmons Short Fiction Award and was named a New York Times Notable Book.Bryan Furunessis the a

uthor of The Lost Episodes of Revie Bryson, a novel. With Michael Martone, he co-edited the anthology, Winesburg, Indiana. His stories can be found in New Stories from the Midwest and Best American Nonrequired Reading, and elsewhere. He lives in Indianapolis, where he teaches at Butler University.Mo

lly Gutman is an MFA candidate in fiction at the University of Nevada, Reno. You can find her stories and poems in Black Warrior Review, Mid-American Review, Hayden’s Ferry review Online, Psychopomp Magazine, The Pinch, and elsewhere.Pam Houston is the author of two collections of linked short stori

es, Cowboys Are My Weakness and Waltzing the Cat. Her stories have been selected for the 1999 volumes of Best American Short Stories, The O. Henry Awards, The Pushcart Prize, and she is a regular contributor to O, the Oprah Magazine, The New York Times, Bark, More, and many other periodicals. A coll

ection of autobiographical essays, A Little More About Me (W.W. Norton), was published in 1999, and a novel, Sight Hound (W.W. Norton) in 2005. Houston has edited a collection of fiction, nonfiction and poetry for Ecco Press called Women on Hunting, and written the text for a book of photographs cal

led Men Before Ten A.M. (Beyond Words, 1996). Her novel, Contents May Have Shifted, was released in 2012 by W.W. Norton.Kirsty Logan is the author of short story collection The Rental Heart and Other Fairytales, awarded the Polari First Book Prize and the Saboteur Award for Best Short Story Collecti

on, and debut novel The Gracekeepers, awarded a Lambda Literary Award. Her most recent book, A Portable Shelter, is a collection of linked short stories inspired by Scottish folktales and was published in a limited edition with custom woodblock illustrations. Her next novel, The Gloaming, is out in

May 2018. She is currently working on a collection of short horror stories, a TV pilot script, and a musical collaboration project.Gregory Maguire is the New York Times bestselling author of Confessions of an Ugly Stepsister; Lost; Mirror Mirror; and the Wicked Years, a series that includes Wicked,

Son of a Witch, A Lion Among Men, and Out of Oz. Now a beloved classic, Wicked is the basis for a blockbuster Tony Award-winning Broadway musical. Maguire has lectured on art, literature, and culture both at home and abroad. He lives with his family near Boston, Massachusetts.Corey Mesler has been

published in numerous anthologies and journals including Poetry, Gargoyle, Five Points, Good Poems American Places, and Esquire/Narrative. He has published 9 novels, 4 short story collections, and 5 full-length poetry collections, and a dozen chapbooks. His novel, Memphis Movie, attracted kind words

from Ann Beattie, Peter Coyote, and William Hjorstberg, among others. He’s been nominated for the Pushcart many times, and 2 of his poems were chosen for Garrison Keillor’s Writer’s Almanac. With his wife he runs a 142 year-old bookstore in Memphis. He can be found at https: //coreymesler.wordpress

.com.Michael Poore is the author of the novels Reincarnation Blues (Del Rey, 2017) and Up Jumps the Devil (Ecco, 2012). His short work has appeared in numerous magazines and anthologies, including The Year’s Best Science Fiction and The Best American Nonrequired Reading 2012. He lives with his wife,

poet Janine Harrison, and daughter Jianna, in Highland, IN.Edward Porter’s short fiction has appeared in Glimmer Train, The Hudson Review, The Gettysburg Review, Colorado Review, Booth, Barrelhouse, Catamaran, Best New American Voices, and elsewhere. He holds an MFA from Warren Wilson College and a

PhD from the University of Houston. He has been a Madison, Macdowell, and Stegner Fellow, and taught creative writing at Milllsaps College. Currently he is a Jones Lecturer in Fiction at Stanford University.

開發小分子藥物用於治療中樞神經系統疾病

為了解決driving classes near的問題,作者曾惠如 這樣論述:

Table of Contents摘要 1Abstract 2I Protein disulfide isomerase-4 inhibitors against glioblastoma: design, synthesis and biological evaluation 3A. Introduction 41. Introduction of glioblastoma 42. Introduction of protein disulfide isomerase 83. Relationship between PDI and cancer 144. Res

earch object and design 16B. Result and Discussion 201. Chemistry 202. Biological evaluation and docking analysis 25C. Conclusion 34II Acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer’s disease: synthesis and biological evaluation 35A. Introduction 3

61. Introduction of Alzheimer’s disease 362. Current therapeutic options and benefit of multitarget agents 383. Introduction of histone deacetylase 394. Relationship between HDAC and AD 415. Introduction of beta amyloid and its relationship with AD 436. Introduction of acetylcholinesteras

e and its relationship with AD 467. Research purpose and design 48B. Result and Discussion 501. Chemistry 502. Biological evaluation and docking analysis 53C. Conclusion 72III Sobrerol derivatives against autoimmune neurologic disease: synthesis and biological evaluation 73A. Introduct

ion 741. Introduction of multiple sclerosis 742. Current therapeutic options and unmet medical need 773. Introduction of interleukin-6 804. Relationship between interleukin-6 and multiple sclerosis 835. Research purpose and design 85B. Result and Discussion 861. Chemistry 862. Biolog

ical evaluation 87C. Conclusion 91Experimental Section 92I. Machine and material 921. General machines and methods: 922. Materials and solvents purchased from: 923. Purification and dehydration of solvent: 95II. Chemistry synthetic routes and physical properties 96A. Protein disulfide

isomerase-4 inhibitors against glioblastoma: design, synthesis and biological evaluation 96B. Acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer’s disease: synthesis and biological evaluation 128C. Sobrerol derivatives against autoimmune neurologic disease: sy

nthesis and biological evaluation 137III. Method of biological assay 146A. Protein disulfide isomerase-4 inhibitors against glioblastoma: design, synthesis and biological evaluation 146B. Acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer’s disease: synthesis

and biological evaluation 148C. Sobrerol derivatives against autoimmune neurologic disease: synthesis and biological evaluation 154Reference 155Supplementary Figures 176List of TablesTable 1. The human PDI family. 10Table 2. IC50 value for the inhibition against PDIA4 by compounds 5b-c 25Tab

le 3. IC50 value for the inhibition against PDIA4 by compounds 11a-c 28Table 4. IC50 value for the inhibition against PDIA4 by compounds 23a-v 29Table 5. Cytotoxicity of PDIA4 inhibitors in glioblastoma cell line, U-87 MG 31Table 6. PAMPA-BBB results of compound 23v and reference compounds 32Tab

le 7. Four stages of Alzheimer’s disease as well as related symptoms. 37Table 8. The human HDAC family. Classes, HDACs, subcellular localization, and structures of HDAC isoforms. 40Table 9. IC50 value (μM) of compounds 31a-d against HDACs. 53Table 10. IC50 value (μM) of compounds 36a-h against HD

ACs 55Table 11. Inhibitory activities of compounds 31a, and 36a-h against Aβ1-42 oligomerization 57Table 12. IC50 value (μM) of compounds 31a, and 36a-h against AChE 58Table 13. IC50 value (μM) of compounds 31a, and 36b against HDAC1, -2, and -3. 59Table 14. EC50 value for increasing acetylation

of histone H3 and tubulin by quantification of western blot. 66Table 15. Metabolic stability of compounds 31a, 36b, and testosterone 69Table 16. BBB permeability evaluation of compounds 31a, and 36b using MDR1-MDCK permeability model 70Table 17. Clinical used disease-modifying therapies of MS 7

8Table 18. Classification of immune-related cytokines. 80Table 19. Cytokines and their functions. 82Table 20. IC50 of sobrerol derivatives in inhibiting IL-6 expression. 89List of FiguresFigure 1. WHO 2016 classification of diffuse gliomas 5Figure 2. FDA approved anti-glioma agents in chemothera

py 7Figure 3. Illustration of disulfide bonds formation and redox reactions involving PDI. 8Figure 4. Schematic overview of PDI structure. 9Figure 5. Schematic overview of relationship between ER stress, UPR, and PDI in cancer cell. 15Figure 6. Chemical structure of reported PDI inhibitors. 17F

igure 7. Flowchart of the process for lead-compound identification. 18Figure 8. Design of potent PDIA4 inhibitors. 19Figure 9. Molecular docking and interaction analysis of compounds 5b and 5c.. 27Figure 10. Molecular docking and interaction analysis of compound 23v. 30Figure 11. Anticancer acti

vities of compound 23v in human glioblastoma U-87 MG xenograft mouse model 33Figure 12. FDA approved drugs in treating AD patients. 38Figure 13. Tau incorporate with HDAC6 to form pathological tau beading. 42Figure 14. Molecular mechanisms of Aβ-oligomers synaptotoxicity 43Figure 15. Graphic ill

ustration of amyloid precursor protein (APP) metabolism 44Figure 16. Graphic illustration of biological action of acetylcholine. 47Figure 17. Reported anti-AD agents with acridine-related structures. 48Figure 18. Reported HDAC inhibitor. 49Figure 19. Design of a novel series of multi-target drug

s for AD treatment. 49Figure 20. Illustration of inhibiting assay of Aβ1-42 oligomerization. 56Figure 21. Illustration of inhibiting assay of Aβ1-42 oligomerization. 56Figure 22. Validation of docking protocol 60Figure 23. Docking pose and interaction of compounds 31a and 36b 61Figure 24. Docki

ng pose and interaction of compound 31a in HDAC6 and HDAC7. 62Figure 25. Docking poses and interactions of compounds 31a and 36b 64Figure 26. Western blot analysis of compounds 31a and 36b in murine neuroblastoma N2a cells 65Figure 27. Graphic illustration of cell viability of compounds 31a and 3

6b 66Figure 28. Enhancement of primary rat hippocampal neurite outgrowth by compounds 31a and 36b 67Figure 29. Quantification of lengths and numbers of primary rat hippocampal neurite branching 68Figure 30. Nesting behavior of APP/PS1 mice treated with compounds 31a and 36b 71Figure 31. Cost of

multiple sclerosis and according economic burden 74Figure 32. Graphic illustration of four categories of multiple sclerosis. 76Figure 33. examples of disease-modifying agents of multiple sclerosis. 79Figure 34. Biological function of interleukin-6 in inflammation, immune, and disease 81Figure 35

. Potential roles of IL-6 in autoimmune neurological disease 84Figure 36. Design strategy of IL-6 secretion inhibitors. 85Figure 37. Bar figure illustration of inhibitory activity of sobrerol derivatives against IL-6 expression 87Figure 38. Structure-activity relationship of sobrerol derivatives.

88Figure 39. Bar figure illustration of cytotoxicity of sobrerol derivatives 90List of SchemesScheme 1. Synthetic route of compounds 5a-c. 21Scheme 2. Synthetic route of compounds 11a-c. 22Scheme 3. Synthetic route of compound 19. 23Scheme 4. Synthetic route of compounds 23a-v. 24Scheme 5. Sy

nthetic route of compounds 31a-d. 50Scheme 6. Synthetic route of compounds 36a-h. 52Scheme 7. Synthetic rout of compounds 38a-r. 86Scheme 8. Synthetic rout of compounds 39. 86