2014 March的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列包括價格和評價等資訊懶人包

Ancient Sources, Modern Appropriations: The Selected Writings of Hans-Georg Gadamer: Volume III

為了解決2014 March的問題，作者Gadamer, Hans-Georg 這樣論述：

Hans-Georg Gadamer was born on 11 February 1900 and died on 13 March 2002. He was the author, most notably, of Truth and Method, and, more recently, of The Beginning of Philosophy and The Beginning of Knowledge.Arun Iyer is an instructor in Philosophy at Seattle University, USA. He is the author of

Towards an Epistemology of Ruptures: The Case of Heidegger and Foucault (2014).Pol Vandevelde is Professor of Philosophy at Marquette University, USA. His previous publications include Être et Discours: La Question du Langage dans L’itinéraire de Heidegger (1927-1938) (1994) The Task of the Interpre

ter: Text, Meaning, and Negotiation (2005) and Heidegger and the Romantics: the Literary Invention of Meaning (2012).

2014 March進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決2014 March的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

The Securely Conferred, Vouchsafed Keepsakes of Maery S.

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為了解決2014 March的問題，作者 這樣論述：

SibylKempson’s plays have been presented in the United States, Germany, and Norway. She launched the 7 Daughters of Eve Thtr. & Perf. Co. in 2015at the Martin E. Segal Center at the City University of New York. The company’sinaugural production, Let Us Now Praise Susan Sontag, premiered at AbronsArt

s Center in NYC the same year. 12 Shouts to the Ten ForgottenHeavens, a 3-year cycle of rituals for the Whitney Museum ofAmerican Art, began on the Vernal Equinox in March 2016, and recurred on everySolstice and Equinox through December 2018. Other recent projects include true pearl, a new opera wit

h David Lang for theIsabella Stewart Gardner Museum in Boston, and Sasquatch Rituals atThe Kitchen in NYC. Both premiered in 2018. Kempson is the recipient of a2018 PEN/Laura Pels International Foundation for Theater Award for AmericanPlaywright at Mid-Career, for writers working indisputably at the

highest levelof achievement, specifically honoring ＂her fine craft, intertextual approach, and her body of work including Crime or Emergency and Let Us Now Praise SusanSontag.＂ She is also a 2014 USA Artists Rockefeller Fellow anda 2010 MacDowell Colony Fellow. With New York Theatre Workshop and di

rector Sarah Benson, she received a 2013Virginia B. Toulmin Foundation Commission for Kyckling and Screaming (atranslation/adaptation of Ibsen’s The Wild Duck), a2013-14 McKnight National Residency and Commission for a new play The Securely Conferred, Vouchsafed Keepsakes of Maery S., and a Frederic

k Loewe Award for Musical Theater for its songs. Kempson is a NewDramatists/Full Stage USA commission for a devised piece entitled From The Pig Pile: The Requisite Gesture(s) of Narrow Approach, and a National Presenters Network Creation Fund Award for the same project. Hersecond collaboration with

David Neumann/Advanced Beginner Group, I Understand Everything Better, received a BessieAward for Outstanding Production in 2015. Her work has been funded by theJerome Foundation, the Greenwall Foundation, the Foundation for ContemporaryArt, and the New York Foundation for the Arts, of which she is

a fellow. WithElevator Repair Service Theater Company, she received a MAP Fund grant for Fondly, Collette Richland at New York Theatre Workshop in 2015. She is a four-time Mondo Cane! commissionee at Dixon Place in NYC. As a performer Kempson touredinternationally with Nature Theater of Oklahoma, Ne

w York City Players andElevator Repair Service from 2000 - 2011.

公有雲端企業資料庫即時同步備援到企業自有機房之研究

為了解決2014 March的問題，作者周建竹 這樣論述：

由於在近十年來網路通訊技術的快速發展，雲端服務在手機時代已經被各企業和個人所採用，在此平台上，提供的服務，可以使租用戶能快速建構符合他們本身所需要的資料系統，另外在以前雲端服務及網路通訊技術尚未普及的年代，資訊系統備援是有地區距離的限制，而現在，在地端和雲端聯結更緊密的時代，在雲端各應用系統的後端的關聯式資料庫儲存重要的交易資料，其中備援設計更是極為重要。在本論文中研究的目的將以雲端的關聯式資料庫層級即時備援到地端，從可用性、即時性、保密安全性、持久性保存和搬遷性等做探討，本研究所採用的方式為在雲端租用和設定環境和地端架設環境，建構本研究之研究模型，進行雲端到地端在關聯式資料庫層級的備援探討

分析，並使用雲端運算業者Azure的計量統計圖表做資料蒐集及資料分析，呈現雲端硬碟讀寫累積使用量和網路頻寬累積使用量的數據並進行分析和探討，企業將可依照自己業務特性，做出符合最佳化的雲端資料庫備援到地端資料庫方式的決策。