Academy的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列包括價格和評價等資訊懶人包

Handbook of Scan Statistics

為了解決Academy的問題，作者 這樣論述：

Joseph Glaz has been recently appointed (effective July 1, 2011) as head of the Department of Statistics, University of Connecticut. He has co-authored 6 books; 4 of which published with either Birkhauser Boston or Springer New York. Glaz is the current editor-in-chief of the following Springer jour

nal: Methodology and Computing in Applied Probability. Honors and Awards include: election to the Connecticut Academy of Arts and Sciences (2011), elected fellow of the Institute of Mathematical Sciences (2009), AAUP Excellence in Research Award (2006), Abraham Wald Prize in Sequential Analysis (200

6), elected fellow of the American Statistical Assoc. (2000), elected member of the International Statistical Institute (1999).Most importantly, Joe Glaz has worked closely with Joseph Naus, the father of scan statistics, since this area of statistics was conceived around 1999.Markos Koutras is curr

ently a full professor in the department of Statistics and Actuarial Science at the University of Piraeus in Greece and served as department chair 2003-2007. He received his PhD in mathematics from the University of Athens in 1983. Koutras serves as a highly active member of the editorial board of t

he Springer journal: Methodology and Computing in Applied Probability and has served on the organizing committee for several international conferences. He has served as referee/reviewer on at least 15 journals and book series. Prof. Koutras had been appointed institutional scientific director of the

modernization of the central library of the University of Piraeus and director of the Graduate Program in Applied Statistics (2001-2004; 2008-2011) at Piraeus.

Academy進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Academy的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Handbook of Scan Statistics

為了解決Academy的問題，作者 這樣論述：

Joseph Glaz has been recently appointed (effective July 1, 2011) as head of the Department of Statistics, University of Connecticut. He has co-authored 6 books; 4 of which published with either Birkhauser Boston or Springer New York. Glaz is the current editor-in-chief of the following Springer jour

nal: Methodology and Computing in Applied Probability. Honors and Awards include: election to the Connecticut Academy of Arts and Sciences (2011), elected fellow of the Institute of Mathematical Sciences (2009), AAUP Excellence in Research Award (2006), Abraham Wald Prize in Sequential Analysis (200

6), elected fellow of the American Statistical Assoc. (2000), elected member of the International Statistical Institute (1999).Most importantly, Joe Glaz has worked closely with Joseph Naus, the father of scan statistics, since this area of statistics was conceived around 1999.Markos Koutras is curr

ently a full professor in the department of Statistics and Actuarial Science at the University of Piraeus in Greece and served as department chair 2003-2007. He received his PhD in mathematics from the University of Athens in 1983. Koutras serves as a highly active member of the editorial board of t

he Springer journal: Methodology and Computing in Applied Probability and has served on the organizing committee for several international conferences. He has served as referee/reviewer on at least 15 journals and book series. Prof. Koutras had been appointed institutional scientific director of the

modernization of the central library of the University of Piraeus and director of the Graduate Program in Applied Statistics (2001-2004; 2008-2011) at Piraeus.

導入智慧建築之實務研究

為了解決Academy的問題，作者戴成煜 這樣論述：

現代人對於科技要求越來越進步，逐漸地也想發展到人的週遭事物方面，而除了智慧型手機外，就是居住環境方面，為了求方便及科技並存，開始發展出智慧建築這項名詞，主要是結合科技、住家、環保等各條件所產生。本研究目的主要是了解建築業者如何將科技導入房屋內，做整合性的服務，並且知道目前智慧建築業者所面臨到的現況與如何去改善。本研究透過質性訪談方式，訪問相關建築背景之負責人來做出探討，探討業界的專家是如何看待智慧建築，以及相關的想法。從研究訪談結果得知，智慧建築業者對於結合物聯網科技，讓使用者可以更加便利，另外智慧建築系統導入社區管理應用與在政策的鼓勵或限制都是會影響的關鍵因素。