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國立臺北科技大學 電資學院外國學生專班(iEECS) 白敦文所指導 VAIBHAV KUMAR SUNKARIA的 An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma (2022),提出Academy 1 72 Su 57關鍵因素是什麼,來自於Lung Cancer、LUAD、LUSC、NSCLC、DNA methylation、Comorbidity Disease、Biomarkers、SCT、FOXD3、TRIM58、TAC1。

而第二篇論文國立勤益科技大學 化工與材料工程系 高肇郎、方國權所指導 高偉順的 台中港區微粒、金屬元素之乾沉降污染物預測、排放來源及健康風險評估之研究 (2021),提出因為有 大氣汙染物、健康風險評估、Global collection model、逆軌跡的重點而找出了 Academy 1 72 Su 57的解答。

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多肽:化學、生物和藥物科學 英文

為了解決Academy 1 72 Su 57的問題,作者王銳 這樣論述:

The 11th Chinese International Peptide Symposium (CPS-2010), hosted by Lanzhou University, was held in Lanzhou, China, July 5-8, 2010. More than 300 participants, from 12 countries and districts as well as represents from 30 or so related companies attended this symposium. Thus, it was gra

tifying to see that this meeting retained both its international flavor and participants loyalty at a time when there are a great many symposia held each year on similar subjects. The goal of this symposium was to provide a forum for exchange of ideas, review of the progress in the field of peptide

research, encourage the cooperation between the international and Chinese scientific communities. We believe that this goal had been achieved. The scientific program, thanks to the insights and efforts of the program committee, was extraordinary rich, diverse and exciting. It was comprised of 14 se

ssions with 22 plenary lectures, 37 invited lectures and 116 poster presentations, concerning bioactive peptides, peptide immunology, structure and conformation of peptides and proteins, molecular diversity and peptide libraries, synthetic methods, de novo design and synthesis of proteins and peptid

es, ligand-receptor interactions, the chemistry-biology-interface, self-assembling peptides and challenging problems in peptides. Dr. John D. Wade and Dr. Yanmei Li were the recipients of ‘Cathay Award’ sponsored by H. H. Liu Education Foundation, offering their seminal contributions to peptide sci

ence and the Chinese International Peptide Symposium. Dr. Saburo Aimoto and Dr. Luhua Lai were the recipients of ‘Xiaoyu Hu Memorial Award’ sponsored by Hainan Zhonghe (Group) Co. Ltd, offering their great contributions in peptide science, peptide application and Chinese International Peptide Sympos

ium. Especially, it should be mentioned that ‘Xiaoyu Hu Memorial Award’ was first set up at the 11th CPS to commemorate Professor Xiaoyu Hu for his great contribution to the development of peptide science and peptide application in China. Four young outstanding scientists were selected by the Intern

ational Program Committee to receive the Young Peptide Scientist Award , which was sponsored by Hainan Zhonghe (Group) Co. Ltd. The enthusiastic cooperation and prominent contributions were gratifying and the active response of the invited speakers contributed to the success of the symposium. The p

resentations were of excellent caliber and represented the most current and significant aspects of peptide science. I would like to acknowledge academicians of chinese academy of sciences, Professor Youshang Zhang and Professor Yundong Wu for their kindness in supporting and serving as the chairman

of the awarding committee for the ‘Cathay Award’ and ‘Xiaoyu Hu Memorial Award’ respectively. The success of the 11th CPS was largely due to the dedication, enthusiasm and hard work of the local organizing committee, who for the most part consisted of volunteers. As Symposium Chair, I am appreciate

d for their contributions very much.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Academy 1 72 Su 57的問題,作者VAIBHAV KUMAR SUNKARIA 這樣論述:

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

台中港區微粒、金屬元素之乾沉降污染物預測、排放來源及健康風險評估之研究

為了解決Academy 1 72 Su 57的問題,作者高偉順 這樣論述:

本研究是使用PS-1採樣器與乾沉降板來蒐集大氣中的懸浮微粒及其附屬重金屬汙染物之濃度及乾沉降,採樣時間於2020年1月至12月於台中梧棲港區來進行。本研究並藉由使用ICP-OES分析儀來分析附著於懸浮微粒上之汙染物的重金屬濃度及乾沉降。再者,本研究亦使用Global model來推估並比較不同粒徑所計算出來之懸浮微粒及其附屬重金屬汙染物之乾沉降通量,其值並與實際之乾沉降值作一比較。除此之外,本研究並利用逆軌跡分析方法來推測台中港區採樣點之可能汙染源。最後,本研究更以風險評估之方法來計算該特徵採樣點之致癌風險值。研究結果顯示,總懸浮微粒濃度與乾沉降通量其最高值均發生於冬季,而重金屬濃度與乾沉降

之最高值則分別為重金屬Cu,Ni。此外,乾沉降模式之研究結果顯示,Global collection model之模式推估乾沉降通量以重金屬元素Pb可得到最佳之乾沉降推估結果。再者,重金屬元素Pb 乾沉降通量之最佳預測結果則出現在 以16 μm 的微粒尺寸作為計算之乾沉降速度則其乾沉降通量能有最佳之推估結果。而逆軌跡分析之結果顯示,本研究之主要汙染氣團於6、7、8月是來自採樣點的南方,其餘月份皆來自於採樣點之北方。而在健康風險評估結果顯示該採樣點之金屬元素Cr的致癌風險值結果高於1×10-4,上述值高於致癌風險監管機構US/EPA之標準。因此,未來宜持續監測觀察上述重金屬Cr元素於台中港區之濃

度及致癌風險值。