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Arthur Frommer’’s Europe

為了解決After through的問題，作者Frommer, Arthur,Ames, Paul,Barron, Peter 這樣論述：

Arthur Frommer The son of a Polish-born mother and an Austrian-born father, Frommer was drafted into the U.S. Army during the Korean War, but was stationed in Europe because of his fluency in German and Russian. During his service, he wrote and self-published a guidebook called The GI’s Guide to Tra

veling in Europe in 1955 that was an immediate hit among his fellow soldiers. In 1957, Frommer created a civilian version called Europe on 5 Dollars a Day, which became an overnight best seller. He subsequently published guidebooks covering all parts of the globe. Frommer licensed his travel guide b

ook business to Simon & Schuster in 1977. Eventually, the Frommer’s series was purchased by John Wiley & Sons, and in August 2012, Google purchased the travel guides. Through all the exchanges, Arthur Frommer was always deeply involved with the guide books. In 2013, Frommer reacquired control of the

guidebooks bearing his name and has come full circle, now self-publishing his iconic travel books again. Additionally, Arthur Frommer writes a travel column syndicated through King Features, and co-hosts a weekly syndicated radio show with his daughter Pauline, ＂The Travel Show with Arthur & Paulin

e Frommer.＂ Arthur resides in New York City. Paul Ames (author Portugal): A native of England’s East Anglia region, Ames has been fascinated by Portugal since a childhood visit in the 1970s when the country was gripped by revolutionary fervor. After 20 years based in Brussels covering Europe for Th

e Associated Press and other international media, he returned to Lisbon in 2013. Paul works as a freelance journalist and never tires of exploring the delights of his adopted homeland, from the green hills of the Minho to sub-tropical Madeira island and all the beaches in between. Peter Barron (auth

or Spain): After careers at the BBC and Google, Peter Barron turned his attention to restoring a barn with his wife Julia at their finca on the border between Andalucía and Extremadura. He has been visiting Spain for over thirty years and loves flamenco guitar, ibérico ham, and manzanilla sherry. He

is one of the authors of Frommer’s Spain and blogs about Extremaduran life at adventuresinextremadura.com. He divides his time between Spain and London. Anna E. Brooke (author France) relocated from her native Britain to Paris in 2000 and hasn’t looked back since. She is now a full-fledged bohemian

, juggling life between freelance travel writing (Frommer’s, Sunday New York Times Travel, Time Out Paris and the Financial Times), children’s fiction, acting and songwriting for film. Jennifer Ceaser (author Belgium and The Netherlands) is a freelance writer and editor who has specialized in travel

journalism for two decades. A former New Yorker and staff editor at the New York Post, Jennifer has lived in Europe since 2016, including Amsterdam, Berlin and Barcelona. She contributes to a variety of publications including Condé Nast Traveler, AFAR, New York magazine, BBC, Time Out, Delta Sky, a

nd Wine Enthusiast. Jason Cochran (author, England & Scotland) was twice awarded Guide Book of the Year by the Lowell Thomas Awards (Society of American Travel Writers) and once by the North American Travel Journalists Association for his book Frommer’s EasyGuide to London. His writing has appeared

in the New York Post, Entertainment Weekly, Travel + Leisure, USA Today, and Budget Travel , among many others. Jason has appeared as a host and commentator on CBS, Fox and AOL, to name a few. He currently is the Editor in Chief of Frommers.com. Donald Strachan (author Italy) is a writer and journal

ist who has written about Italy for publications worldwide, including National Geographic, the Guardian, Sunday Telegraph, and the Independent. Rachel Glassberg (author Austria, Germany, Switzerland) is a Berlin-based journalist last seen traversing the Alps for Frommer’s Switzerland and ruining he

r friends’ favorite bars for Frommer’s Germany. Formerly deputy editor of the English-language city magazine Exberliner, she now divides her time between writing, music, and travel -- sometimes two or even all three of those simultaneously.

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區塊鏈技術在台灣二手車市場應用之實證研究

為了解決After through的問題，作者蘇祐 這樣論述：

近年來的二手車市場交易量皆比新車市場高的多，且每年逐漸上升，此市場日益壯大，價格機制卻還是相當混亂，相當不透明，故此本研究以改善台灣二手車市場資訊不對稱問題為發想，設計一套網頁系統，以以太坊區塊鏈為系統底層，且成立一個二手車聯盟來管理該系統，有意願加入此系統的車主需將車輛移至與聯盟配合之檢修場，在確認資料無誤後，聯盟會將該車輛的資料上傳至區塊鏈系統上，以供系統參與者查閱。 本研究透過設計區塊鏈系統進行實作實驗，依據區塊鏈的不可篡改性來用以改善台灣二手車市場資訊不對稱問題，並使用Node.js SDK工具提供網頁客戶端，模擬車輛資料上傳的流程，最後提出三項實驗數據以檢驗新的系統架構設計適確性

，以及檢驗資料的正確性。實驗結果顯示，本研究所提出之二手車區塊鏈系統確實可改善二手車市場資訊不對稱的問題，藉由區塊鏈的不可篡改性，讓資料上傳後就無法修改，就算覆蓋過去鏈上也都能查到相對的紀錄，確保鏈上資料的正確性，讓其餘參與者在系統上查閱時，能夠信任這份資料，進一步改善過去消費者只能以車主所提供之資料作為參考，讓二手車市場資訊更加透明，進一步提高消費者對市場的滿意度及忠誠度。

The Addison Diaries: Natal Carbineer, Gunner, Pioneer Farmer - the Life and Times of Frederick Addison 1894–1969

為了解決After through的問題，作者Addison, Walter 這樣論述：

Frederick Addison came from a family with a strong military tradition, and it is not surprising that he, his two brothers, and two cousins all joined the Royal Natal Carbineers on the same day in 1914, soon after war was declared. They served together through the German South-West African campaig

n, and again in France with the Second South African Infantry Brigade. Two of them were killed, one was taken prisoner, and all were wounded. While the core of the book is a grim account of his experiences during World War I, and there is no doubt that the traumatic events described in the war diari

es had a powerful influence on the rest of his life, Frederick Addison's memoirs cover his entire lifetime. His detailed description of a wild childhood in Estcourt, where his father served as the magistrate during and after the Boer War, his record of spartan schooldays at Hilton College, and his a

ccounts of life as a pioneer sugar farmer on the Natal North coast are all told with vigor, humor and a rugged compassion. His chronicle includes a brief history of the Thukela River basin, description of early post-cart journeys in pre-world war Zululand and recollections of farming, farmers and fa

rm workers in and around Fort Pearson in the years 1919- 1954. A history of the Addison family, written originally for his many relatives in South Africa and abroad, is included as an appendix to the narrative. It is full of anecdotes which shed an intimate light on the early days of settler life in

Natal. In all, a graphic record of the life and times of Frederick Addison - shared, no doubt, by many of his generation.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決After through的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.