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End Game: Does Israel Have a Plan?

為了解決Approach的問題，作者Sachs, Natan 這樣論述：

How Israelis envision and plan for the future of their countryDoes Israel have a plan? What does the country want to look like in 10 or 20 years? What borders does it hope to have? Will the West Bank or the Gaza Strip be part of it? Will the Palestinians residing the territories be granted citizensh

ip and become Israeli citizens? Does the country as a whole even know what it wants, what its goals are, or how to achieve them?Israel faces a fundamental question, a "trilemma." It can choose only two of three different goals many Israelis hold dear: to maintain control over the West Bank, with its

strategic and religious significance to Israel; to retain a clear Jewish majority, the goal of the Zionist movement that founded the state; or to remain a democracy, with full voting rights for all citizens.This trilemma has caused world leaders and publics, Israel-supporters and critics, to wonder

aloud time and again: what does Israel want? If it wishes to maintain its Jewish and democratic character, surely it must separate from the West Bank and its population; why then does Israel keep building in Israeli settlements in the West Bank, making such separation all the more difficult? And if

it plans to retain control over the West Bank, is it really willing to give up on either its Jewish nature or its democracy?End Game attempts to solve the puzzle of why the Israeli strategic vision seems so elusive to many foreigners and Israelis alike. It explores how Israelis' beliefs about their

future are formed and how their visions are translated into policy, focusing on three factors in depth: the role of security concerns, ideology, and domestic political constraints that combine to shape Israel's strategic posture.The book contrasts the full range of views in Israel over the future o

f the West Bank, from supporters of a bi-national state or confederacy on the left, to supporters of a "one state" on the far right of the political spectrum. It pays particular attention to the worldview of the political center-right, led by Prime Minister Benjamin Netanyahu, a conservative, risk-a

verse and "anti-solutionist" approach to the problem. This worldview, following decades of precedent, rejects the need for a full-fledged strategic "solution" to the problem, leading to widespread confusion over Israel's goals. The book analyses and critiques this approach, arguing forcefully for en

ding Israeli indecision over the future of the land and in favor of partition and, eventually, peace. Dr. Natan Sachs is a fellow in the Center for Middle East Policy at the Brookings Institution. His research focuses on Israel’s foreign policy, its domestic politics, and on U.S.-Israeli relations

. Before joining Brookings, Sachs was a Hewlett Fellow at Stanford’s Center on Democracy, Development and the Rule of Law, a Fulbright Fellow in Indonesia, and a Visiting Fellow at Tel Aviv University’s Dayan Center for Middle Eastern and African Studies.

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技術型高中學生學習歷程檔案學習動機及其學習成效之關係研究-以桃竹苗地區為例

為了解決Approach的問題，作者羅筱恩 這樣論述：

摘要 本研究旨在探討公立技術型高中學生學習歷程檔案學習動機及其學習成效之關係研究。以108學年度入學就讀桃竹苗地區公立技術型高中學生為研究對象，採問卷調查法。發出8校900份問卷，回收有效650份問卷後經資料整理，再透過SPSS 20統計軟體進行資料處理與分析，探討技術型高中學生學習歷程檔案的學習動機及其學習成效之相關情形，進行敘述性統計及推論性統計之分析與討論。依據研究目的，本研究獲致結果如下：壹、桃竹苗地區學生學習歷程檔案以期望成分的學習動機認同度最高，以學習成果的學習成效認同度最高。貳、學生學習歷程檔案以女性學生、就讀家事類、苗栗地區以及上傳課程學習成果與多元學習表現件數多者的學

習動機認同度較高。參、學生學習歷程檔案以女性學生、就讀家事類、苗栗地區以及上傳課程學習成果與多元學習表現件數多者的學習成效認同度較高。肆、桃竹苗地區學生學習歷程檔案學習動機及其學習成效呈現高度正相關。關鍵字：技術型高中學生、學生學習歷程檔案學習動機、學生學習歷程檔案學習成效

Essays on Aristotle’s Eudemian Ethics

為了解決Approach的問題，作者Heinaman, Robert (EDT) 這樣論述：

Two major works on ethics have come down to us under Aristotle's name, the Nicomachean Ethics and the Eudemian Ethics, but, quite unjustifiably, the Eudemian Ethics has been largely neglected by students of ancient philosophy. This important collection of essays from the sixth Keeling colloquium on

ancient philosophy tries to rectify this one-sided approach to Aristotle's ethics by focusing on the positions and arguments of the Eudemian Ethics. As the essays demonstrate, Aristotle's views in the Eudemian Ethics frequently differ in interesting and surprising ways from those found in the Nicoma

chean Ethics and deserve study for their own sake, not merely for purposes of comparison with the Nicomachean Ethics. The contributors include some of the best known Aristotle scholars of the present day. Christopher Rowe and Jennifer Whiting investigate the Eudemian Ethics' account of friendship (p

hilia) while M.M. McCabe examines the closely related issue of self-knowledge in EE VII.12. Stephen White analyzes the Eudemian Ethics' account of eudaimonia, David Charles focuses on voluntary action, and Friedemann Buddensiek investigates Aristotle's difficult discussion of good fortune (eutuchia)

in EE VIII.2. The volume also contains critical discussions of these papers provided by commentators, who, along with Whiting and McCabe, include Julia Annas and Sarah Broadie. Dr Robert Heinaman, Reader in Philosophy, University College London, UK

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Approach的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.