Discovery的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列包括價格和評價等資訊懶人包

Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable

為了解決Discovery的問題，作者 這樣論述：

Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable uses real-world case studies to illustrate how critical thinking and problem-solving skills are applied and necessary in the discovery and development of drugs. The book shows how the development of critical th

inking to overcome issues plays an essential role in scientific and professional expertise. As addressing critical, unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills, this book is an ideal training manual on how to ov

ercome obstacles. It will be essential to young scientists who want to develop the skills to successfully face challenges, learn from their mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from case studies of successful and

unsuccessful drug development

Discovery進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Discovery的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Media Narratives in Popular Music

為了解決Discovery的問題，作者 這樣論述：

Chris Anderton is Associate Professor in Cultural Economy at Solent University, UK. He has published on a variety of topics including the recorded and live music industries, music festivals, music history, music culture, music marketing, music cities, event management, and the intersection of fan pr

actices and intellectual property law. He is the author of Music Festivals in the UK: Beyond the Carnivalesque (2019) and co-author of both Understanding the Music Industries (2013) and Music Management, Marketing and PR: Creating Connections and Conversations (in press). He is also co-editor of Res

earching Live Music: Gigs, Tours, Concerts and Festivals (in press). Martin James is Professor of Creative and Cultural Industries at Solent University, UK. His areas of specialist interest include music journalism and the music press, music and cultural cities, and late twentieth-century alternativ

e music; specifically punk, post punk and electronic musics. Martin’s publications have focused on hidden histories in the mediated narratives of popular music. He is author of several critically acclaimed books about music, including French Connections: From Discotheque to Discovery (2003), State o

f Bass: Jungle - The Story So Far (1997; 2020) and co-authored Understanding the Music Industries (2013).

約翰福音二十章1–18節中抹大拉馬利亞的轉變—以格雷馬斯行動素模型理論分析探討

為了解決Discovery的問題，作者劉虹君 這樣論述：

本論文旨在透過格雷馬斯（A. J. Greimas）的「行動素模型（Actantial Model）理論」，分析探討約翰福音二十章 1–18 節中抹大拉馬利亞的轉變。馬利亞在此復活敘事中，從一開始誤解空墳、跑向門徒求助，到最後被主所用，能堅定去向門徒、傳講耶穌復活並祂所吩咐的信息，可看出她經歷了重大的轉變。但本論文認為此轉變並非只來自於她發現耶穌復活，因她認出耶穌後，竟還做出耶穌所禁止的事（即拉住耶穌，參約 20:17），可見當時的馬利亞尚未轉變為「合上帝心意」或「能被上帝使用」的狀態。透過行動素模型理論對經文深層結構的分析，發現耶穌的「呼喚名字」、「自我啟示」、「賦予使命」以及馬利亞自己的

「信而順服」是影響她轉變的四大因素，且其轉變乃關乎她對耶穌以及對自己認知上的改變:她真正認識到耶穌是上帝的兒子，同時她也意識到，過去身為女性沒有地位、沒有價值的自己，如今竟因著耶穌，有了榮耀的身份與使命。這一切使她終能放下自己的渴望，單單順服於耶穌，成為主所使用的器皿。而透過對馬利亞的研究，也得出基督徒生命更新變化的三要素，即對上帝有正確確實的認知、對自己有正確確實的認知（知道其有限並上帝所賦予的價值與使命），以及人願意相信順服的心。