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Adventures in Feminist Dramaturgy: The Road Less Traveled

為了解決Forge的問題，作者Hope, Laura Lee/ Kelly, Philippa 這樣論述：

In their lively invocation of a feminist dramaturgy that can lead to innovative and challenging directions in modern theatre-making, Laura Hope and Philippa Kelly make use of first-hand interviews with directors, actors, designers, and critics, as well as their own experiences in the theatre, to ope

n up feminist dramaturgy as a field of enquiry and performance possibility. The authors begin by discussing what happens when a dramaturg's performance strategies are vastly different from what a director envisions. This discussion moves naturally to Hope and Kelly's analysis of canonical plays they

hope to re-think in terms of gender at the same time that they resist the implication that a feminist perspective is a prescription for a political and social agenda. Casting a critical eye on "mainstream" approaches to classical plays, the authors revisit casting practices, editing philosophies, a

nd directorial concepts that provide thin, stereotypical depictions of male and female characters, arguing for closer textual and cultural analyses of misguided ventures such as the Lysistrata Project. Their commentary on appeals to audience involvement highlights the difficulty of challenging audie

nce preconceptions and the possibilities for expanding audience reception, while the counterproductive rigidity with which organizations like the Beckett estate resist new approaches to theatrical production are exposed in a discussion of feminist dramaturgy's potential to reinvigorate a play like W

aiting for Godot. Adventures in Dramaturgy concludes with the authors' personal journey to forge new directions within a specific theatre company and in the professional world at large. Laura Hope is Assistant Professor of Theatre at Loyola University New Orleans and Philippa Kelly is Resident Dra

maturg at the California Shakespeare Theater, USA.

Forge進入發燒排行的影片

多功能環保量子點作為靶向雙成像和光動力癌症治療平台

為了解決Forge的問題，作者諾菲 這樣論述：

Recommendation letter iiAbstract in chinese iiiAbstract in english vAcknowledgments viiContents viiiList of figures xiiList of tables xviiList of abbreviation ixChapter 1. Introduction 11.1 General introduction 21.2 Objective of study 61.3 Structure of the dissert

ation 6Chapter 2. Literature review 82.1 Nanoparticles 92.2 Semiconductor quantum dots 102.3 The quantum confinement, optical properties, and core/shell structure of QDs 122.4 Synthesis of QDs 192.4.1 Nucleation and growth 212.4.2 Hot injection method 252.4.3 Heat-up method

282.4.4 Solvothermal approach 312.4.5 Hydrothermal approach 332.4.6 Microwave irradiation approach 352.5. Folate receptor targeting agents 382.6 QDs biomedical applications 422.6.1 Optical imaging 422.6.2 Magnetic resonance imaging (MRI) 442.6.3 Drug delivery 462.6.4 Photo

‑dynamic therapy (PDT) and Photo‑thermal (PTT) therapy 59Chapter 3. Manganese-doped green tea-derived carbon quantum dots as a targeted dual imaging and photodynamic therapy platform 483.1 Introduction 523.2 Experimental methods 533.2.1 Materials 553.2.2 Synthesis of Mn-CQD 563.2.

3 Preparation of Mn-CQDs@FA/Ce6 563.2.4 Characterization 573.2.5 Cell structure and viability evaluation 583.2.6 In vitro photodynamic cancer cells’ ablation 593.2.7 Cell imaging 603.3 Results 603.3.1 Synthesis of Mn-CQDs 603.3.2 Preparation of Mn-CQDs@FA/Ce6 643.3.3 Photolu

minescence characteristics and ROS generation of Mn-CQDs@FA/Ce6 conjugates 663.3.4 Mn-CQDs as MRI contrast agents 693.3.5 In vitro cellular uptake and therapeutic effect 723.4 Discussion 753.5 Summary 77Chapter 4. Multifunctional MnCuInSe/ZnS quantum dots for bioimaging and photodyna

mic therapy 794.1 Introduction 804.2 Experimental methods 834.2.1 Materials 834.2.2 Synthesis of the CuInS, CuInSe, MnCuInSe core and CuInS/ZnS, CuInSe/ZnS and MnCuInSe/ZnS core/shell carbon quantum dots 844.2.3 Characterization 854.2.4 Optical and photoluminescence properties of

MnCuInSe/ZnS assay 854.2.5 Photoactivity assessment of MnCuInSe/ZnS 864.2.6 In Vitro MR 864.2.7 Cell culture and in vitro cytotoxicity evaluation 874.2.8 Cell imaging 884.3. Results and discussion 884.3.1. Synthesis and characterization of MnCuInSe/ZnS 884.3.2 Optical and photol

uminescence properties of MnCuInSe/ZnS 904.3.3 Stability of MnCuInSe/ZnS QDs colloidal solution 944.3.4 ROS generation of MnCuInSe/ZnS 974.3.5 Magnetic resonance imaging 984.3.6 In vitro cellular uptake and therapeutic effect 1014.3.7 Confocal imaging 1024.4. Summary 105Chapte

r 5. Conclusions 1065.1 Conclusions 1075.2 Future outlooks 109References 110Appendix 134

50 Gems of South Yorkshire: The History & Heritage of the Most Iconic Places

為了解決Forge的問題，作者Handley, Christine,Rotherham, Ian D. 這樣論述：

The county of South Yorkshire covers Barnsley, Doncaster, Rotherham and Sheffield districts. Although each are major urban centres with their own range of civic buildings, museums and galleries, the county also ranges from low-lying farmlands in the east to high moorlands on the edge of the Peak

District National Park. It has a rich and diverse landscape including ancient woodlands, rivers and wetlands alongside the legacy of its history as an industrial powerhouse built on coal, steel and heavy engineering, including Kelham Island in Sheffield, Wortley Top Forge and Silkstone Tramway in Ba

rnsley, and Clifton Museum in Rotherham. Away from the urban centres there are picturesque market towns and villages, such as Penistone, Tickhill, Bawtry, Bradfield, Thorpe Salvin and Tankersley which still serve rural farming communities, and stunning stately homes and parkland, for example at Went

worth Woodhouse, Canon Hall and Brodsworth Hall. Earlier medieval remains survive at Roche Abbey and Monk Bretton Priory, the castle keep at Conisbrough, the Lady Chapel on the bridge in central Rotherham and Ecclesfield Church, ’the Minster of the Moors’. There are also examples of the earliest hum

an settlement and activity at Wharncliffe Crags and Wincobank Hill in Sheffield. Other places have associations with historical figures such as the sculptor Francis Chantrey and William Bradford, one of the Pilgrim Fathers. In 50 Gems of South Yorkshire authors Christine Handley and Ian Rotherham ex

plore the many places and their history that make this part of northern England so special, including many lesser known gems.

設計多刺激響應性中孔奈米載體攜帶Doxorubicin/MicroRNA-34a用於藥物釋放和體外/體內抗癌之評估

為了解決Forge的問題，作者杜米 這樣論述：

多年來，癌症已成為全球主要死因，2018 年已造成約 960 萬人死亡。預測表明，到 2030 年，每年將有約 2600 萬新癌症病例和 1700 萬癌症死亡病例。化療提高了癌症患者的生存率；但副作用大，療效差，無法區分腫瘤細胞和正常細胞，導致癌症患者死亡率高。佔嬰兒所有癌症的 6% 的神經母細胞瘤起源於神經嵴內的交感腎上腺祖細胞。大約 25% 的神經母細胞瘤病例是由 MYC 相關癌基因 MYCN 擴增引起的，從而導致疾病風險高和預後不良；因此，關注MYCN抑制的研究是必不可少的。有趣的是，microRNA-34 (miR-34) 因其致癌和腫瘤抑制能力而成為癌症治療的潛在候選者。本研究介紹

了陽離子磁性奈米複合材料 (MNC) 的合成、鑑定和應用，該複合材料包含支鏈聚乙烯亞胺 (bPEI) 包覆的磁性氧化鐵 (MIO) 奈米粒子。這些帶正電荷的 MNC 具有穿透帶負電荷的細胞壁的能力，以將 miR-34a 分子遞送到癌細胞中。在 3380、1620、2900 和 2840 cm-1 處對應於 −NH−和−CH2− 基團的特徵峰表明 bPEI 成功塗覆在 MIO 奈米顆粒表面。通過使完全遞送的載體劑量能夠非常快速地濃縮到細胞上的磁場提高了轉染效率。此外，小角中子散射 (SANS) 的結果表明，產生核心熱量並隨後導致殼軟化，這是由替代磁場 (AMF) 激活的。 3-(4,5-dime

thylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) 測定表明，MNCs 對受試細胞沒有任何顯著毒性。 miR-34a 擴增的增加導致了 MYCN 蛋白的抑制，從而抑制了神經母細胞瘤細胞的生長。肝癌是世界範圍內最普遍和第三大常見的癌症死亡率基礎，不幸的是，它的治療往往受到缺乏適當的治療選擇和當前治療方法引起的副作用的限制。此外，bPEI聚合物與PF聚合物進一步交聯，隨後塗覆在MIO奈米顆粒表面，得到MIOpoly。隨後的應用結果表明，觀察到 pH（48 h 後釋放 54.8%）和溫度（48 h 後釋放 51.0%）依賴的 DOX 釋放，

其中在 pH = 5.4 和更高溫度 42 °C 時釋放更多 DOX。 MIOpoly-DOX 觀察到的更高 DOX 熒光錶明替代磁場增強了高細胞攝取。此外，配製了負載多柔比星 (DOX) 的 pH 響應/熱響應磁性介孔奈米載體，並評估了它們對肝癌的體外抗癌活性。這些奈米載體由羥基磷灰石 (HAP) 和與 MCM-41/SBA-15 和 Pluronic F127 結合形成 MSNs@P123 和 MIOS15@PF 奈米載體的 MIO 奈米顆粒組成。製備的 IMNPs 和 MIOS15@PF 奈米載體具有高飽和磁化強度的超順磁性。 SANS 和小角 X 射線散射 (SAXS) 研究表明，開發

的奈米載體對溫度敏感並具有六邊形排列的結構。細胞活力研究表明，MSNs@P123-DOX 和 MIOS15@PF@DOX 奈米複合物誘導更多的細胞凋亡或壞死。觀察到溫度（48 小時後釋放 69%）和 pH（48 小時後釋放 70%）依賴的 DOX 釋放，其中在 42 °C 的高溫下釋放更多的 DOX，觀察到 MIOS15 的 pH 值為 5.4 @PF@DOX 載體。體內動物試驗研究表明，製備的奈米載體能夠抑制所有受試小鼠的肝腫瘤。因此，所開發的奈米載體在靶向遞送常規化療藥物方面具有巨大的潛力，並且效率更高。