GT SONIC的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列包括價格和評價等資訊懶人包

Moroccan Other-Archives: History and Citizenship After State Violence

為了解決GT SONIC的問題，作者El Guabli, Brahim 這樣論述：

Moroccan Other-Archives investigates how histories of exclusion and silencing are written and rewritten in a postcolonial context that lacks organized and accessible archives. The book draws on cultural production concerning the ＂years of lead＂--a period of authoritarianism and political violence

between Morocco’s independence in 1956 and the death of King Hassan II in 1999--to examine the transformative roles memory and trauma play in reconstructing stories of three historically marginalized groups in Moroccan history: Berbers/Imazighen, Jews, and political prisoners. The book shows how Mo

roccan cultural production has become an other-archive: a set of textual, sonic, embodied, and visual sites that recover real or reimagined voices of these formerly suppressed and silenced constituencies of Moroccan society. Combining theoretical discussions with close reading of literary works, the

book reenvisions both archives and the nation in postcolonial Morocco. By producing other-archives, Moroccan cultural creators transform the losses state violence inflicted on society during the years of lead into a source of civic engagement and historiographical agency, enabling the writing of hi

stories about those Moroccans who have been excluded from official documentation and state-sanctioned histories. The book is multilingual and interdisciplinary, examining primary sources in Amazigh/Berber, Arabic, Darija, and French, and drawing on memory studies, literary theory, archival studies,

anthropology, and historiography. In addition to showing how other-archives are created and operate, El Guabli elaborates how language, gender, class, race, and geographical distribution are co-constitutive of a historical and archival unsilencing that is foundational to citizenship in Morocco today

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GT SONIC進入發燒排行的影片

探討內皮細胞特異分子在攝護腺癌進程之角色

為了解決GT SONIC的問題，作者潘可梵 這樣論述：

雖然Wnt/β-catenin訊息傳遞路徑的活化常見於晚期攝護腺癌中，然而其訊息傳遞路徑上的相關基因突變在攝護腺癌中卻十分少見，因此這條訊息傳遞路徑在攝護腺癌中可能存在未知的調控機轉。在此篇研究中，我們發現一種分泌型多醣蛋白Endothelial cell-specific molecule 1 (ESM1)的表現量與攝護腺癌的進程及轉移具高度相關性，且ESM1表現較高的病人其總體存活率較低。ESM1可透過活化Wnt/β-catenin訊息傳遞路徑調控癌細胞的幹性以促進攝護腺癌的進程。此外我們也發現ESM1在侵犯程度較高的攝護腺癌細胞核內高度表現，而這群在核內的ESM1相較於其原始的分泌狀態

更可支持攝護腺癌幹性。透過與β-catenin的armadillo (ARM) repeat domain結合，ESM1可幫助穩定β-catenin及其cofactor T-cell factor 4 (TCF4)的聚合體，進而促進Wnt/β-catenin訊息傳遞路徑持續地活化。同時，活化的β-catenin也會幫助ESM1進入細胞核內，進一步促使ESM1/β-catenin/TCF4聚合體於核內停留並活化下游調控分子。我們的研究證實了核內的ESM1在攝護腺癌轉移過程的關鍵調控角色，可望成為一新穎的預後生物標記及藥物標靶。

Addicted to Noise: The Music Journalism of Michael Goldberg

為了解決GT SONIC的問題，作者Goldberg, Michael 這樣論述：

Addicted to Noise collects the best interviews, profiles, and essays Michael Goldberg has written during his forty-plus years as a journalist. From combative interviews with Frank Zappa and Tom Waits to essays on how Jack Kerouac influenced Bob Dylan and the lasting importance of San Francisco’s

first punk rock club, Goldberg, as novelist Dana Spiotta wrote, ＂shows us how consequential music can be.＂ Contained within these pages: interviews with Sleater-Kinney, Sonic Youth, Patti Smith, Lou Reed, Flipper, John Fogerty, Neil Young, and Rick James, along with profiles of Robbie Robertson, Joh

n Lee Hooker, James Brown, the Clash, Prince, Michael Jackson, the Flamin’ Groovies, Ramblin’ Jack Elliott, X, Laurie Anderson, Stevie Wonder, George Clinton, Devo, San Francisco punks Crime, and more. Plus short takes on Muddy Waters, Townes Van Zandt, Captain Beefheart, Professor Longhair, and oth

ers. As Greil Marcus writes in the Foreword, ＂You can feel the atmosphere: someone has walked into a room with a pencil in his hand--as the words go in perhaps the first song about a music critic, not counting Chuck Berry’s aside about the writers at the rhythm reviews--and suddenly people are relax

ed . . . He isn’t after your secrets. He doesn’t want to ruin your career to make his. He doesn’t care what you think you need to hide. He actually is interested in why and how you make your music and what you think of it. So people open up, very quickly, and, very quickly, as a reader, you’re not r

eading something you’ve read before.＂

治療鼻咽癌的新標的與藥物

為了解決GT SONIC的問題，作者許彥彬 這樣論述：

放射治療合併以cisplatin為基礎的化療藥物是針對較晚期鼻咽癌病患的主要治療方式。但鼻咽癌患者在治療後可能出現嚴重的併發症，部分病患則可能有腫瘤復發或遠處轉移的情形。此外，目前的化學治療藥物仍無法有效的治療殘存的或遠處轉移的癌症細胞。因此，找尋新的鼻咽癌治療藥物或治療方式有其臨床上的重要性。在我們先前的研究中發現了幾個對治療鼻咽癌有潛力的新藥物。在這些新藥物中，我們挑選了thiostrepton，進一步在鼻咽癌細胞株上驗證它的角色與效果。Thiostrepton為一天然的thiazole類抗生素，以其治療鼻咽癌細胞，可抑制癌細胞增生，且效力隨藥物濃度增加而增強。此外，thiostrept

on也可抑制鼻咽癌細胞的移動能力及侵犯能力。藉由以Ingenuity Pathways Analysis分析microarray資料，我們找出了與其相關的治療機轉及基因表現。除了驗證新藥物的效力外，我們也找到治療鼻咽癌的一個潛在新標的。Podoplanin是一個跨膜的糖蛋白，在我們的研究中發現podoplanin在大部分的TW01株鼻咽癌細胞中均有表現，而以siRNA抑制podoplanin可以降低鼻咽癌細胞的增生、移動與侵犯能力。我們也利用microarray分析，找出了與此相關的正向調控和負向調控基因，並發現最相關的路徑為interferon signaling pathway。綜合以上的

研究結果，顯示thiostrepton有潛力成為治療鼻咽癌的新藥物，而podoplanin則有潛力成為治療鼻咽癌的新標的，我們的研究提供了未來治療鼻咽癌的新策略。