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The Horn Engaging the Gulf: Economic Diplomacy and Statecraft in Regional Relations

為了解決Horn的問題，作者Ylönen, Aleksi 這樣論述：

Aleksi Ylönen is an Associate Professor of International Relations at USIU - Africa, Kenya. He has over a decade of experience in conducting research on politics and armed conflicts in the greater Horn of Africa. His research has been published in scholarly journals, books and other outlets in a num

ber of languages. His most recent book, The Horn of Africa Since the 1960s, was published in 2017.

Horn進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Horn的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Bomb (Graphic Novel Edition): The Race to Build--And Steal--The World’s Most Dangerous Weapon

為了解決Horn的問題，作者Sheinkin, Steve 這樣論述：

Steve Sheinkin is the acclaimed author of fast-paced, cinematic nonfiction histories for young readers, including Bomb, Fallout, Undefeated, Born to Fly, and The Port Chicago 50. His accolades include a Newbery Honor, three Boston Globe-Horn Book Awards, a Sibert Medal, and three National Book Award

finalist honors. Sheinkin lives in Saratoga Springs, New York, with his wife and two children. stevesheinkin.com Nick Bertozzi has written and drawn many comics over the years, including Becoming Andy Warhol, The Salon, Lewis & Clark, and the New York Times bestselling Shackleton: Antarctic Odyss

ey. Bertozzi has won multiple Harvey and Eisner awards, the highest honors in comics. He lives in Queens, New York, with his wife and daughters. nickbertozzi.com

以一步驟表面電漿誘發剝離法製備氮摻雜碳化鉬/石墨烯奈米片複合材料及其性質和產氫催化性能

為了解決Horn的問題，作者呂弈均 這樣論述：

在此論文中，講述運用一步驟表面電漿誘發剝離法，製備碳化鉬/石墨烯奈米片複合材料和氮摻雜碳化鉬/石墨烯奈米片複合材料，探討碳化鉬和石墨烯奈米片的比例對表面形貌、材料性質和其應用於電催化產氫中的催化劑表現，並以前者最佳催化表現的比例進行氮摻雜探討異質摻雜對表面形貌、材料性質和其應用於電催化產氫中的催化劑的影響。一步驟表面電漿誘發剝離法是先以石墨紙為基材製備雙層電極，再將雙層電極接到陰極、1M硫酸為電解液，通以70伏特的電壓，在陰極尖端會產生電漿並從雙層電極上剝離複合材料到電解液中，再把電解液抽氣過濾即可得到產物。使用SEM和TEM觀察碳化鉬/石墨烯奈米片複合材料的呈現互相交疊的情形，碳化鉬表面變

崎嶇、尺寸變小，石墨烯奈米片則呈現奈米片狀結構；以EDS和XPS分析可以得知添加氮源可對複合材料中的碳化鉬進行氮摻雜；透過拉曼光譜儀可以得知複合材料中的石墨烯奈米片為少層數；以XRD對材料進行分析和文獻比對後可以得知複合材料中的碳化鉬為beta相結構；把材料以一定比例塗在碳玻璃電極上進行電化學量測，透過LSV量測可得知碳化鉬/石墨烯奈米片複合材料中的最佳過電位是GM-300，數值為247mV，氮摻雜碳化鉬/石墨烯奈米片複合材料中最佳過電位是GM-N50，數值為185mV。塔弗曲線圖中，碳化鉬/石墨烯奈米片複合材料中的塔弗斜率最好的是GM-300，數值為86(mV/dec)，氮摻雜碳化鉬/石墨烯

奈米片複合材料中斜率最好的是GM-N50，數值為70(mV/dec)。一步驟表面電漿誘發剝離法能成功同時複合材料進行剝離和異質摻雜，而且此製程有著快速、便宜和單步驟完成製程等優勢，是一項具有研究潛力的製程，未來可以替換其他產氫催化材料進行複合材料的研究。