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The Idea of Black Culture

為了解決In latest的問題，作者Spillers, Hortense 這樣論述：

Hortense Spillers is Professor of Literature at Cornell. She is currently chair of the African-American section of the MLA; she is a regular participant in the celebrated School of Criticism and Theory at Cornell, a Norton Editor (with Gates on the Norton Anthology of African Americna Literature, an

d a contributor to the Schomberg Library of Nineteenth-century Black Women Writers; her latest work, forthcoming from U of Chicago Press, was recently the subject of a mini-conference at U Pennsylvania. Her publications include: Conjuring: Black Women, Fiction and Literary Tradition (1985); Comparat

ive American Identities: Race, Sex, and Nationality in the Modern Text (1991).

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決In latest的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Cancer Immunotherapy: Principles and Practice

為了解決In latest的問題，作者Boyiadzis, Michael M. 這樣論述：

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.A complete primer on the medical uses of immunotherapyCancer Immunotherapy: Principles and Practice offers th

orough coverage of this emerging topic - from fundamentals and basic science to clinical application and toxicity management. The cutting-edge content, written by a world-renowned author team is presented in a concise, templated, easy-to-read format, and includes the latest guidelines for immunother

apy and toxicity management

少量語料實現端到端的語音合成系統

為了解決In latest的問題，作者劉宇軒 這樣論述：

本論文透過深度學習的技術改善英文語音合成的音質，建立一個音質改善的英文文字轉語音系統。本研究從最基本的聲學參數及語言參數去做改善，在頻譜參數方面引入WORLD分析的CheapTrick作為求取頻譜資訊之方法，而標記資訊方面加入音素、音節、詞、片語、句子五層結構的相關位置的語言資訊，文字分析方面則是實作一個系統產生標記資訊，模型訓練方面則是引入深度學習的深度混合密度網路架構幫助我們建立頻譜模型及持續時間模型，再加上深度學習的WaveNet聲碼器取代傳統的MLSA聲碼器做合成，最後引用Tacotron模型實現端到端的語音合成系統。實驗結果證實HTS系統的合成聲音在喜好度及MOS兩種主觀測試上有很

大進步，而Tacotron系統則在訓練的效率上有很大改進。