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Recent Advances in Mechanical Engineering: Select Proceedings of Icrame 2020

為了解決LIKE COLOMBO 150的問題，作者 這樣論述：

Prof. K.M. Pandey obtained B.Tech in Mechanical Engineering from BHUIT, Varanasi now known as IIT BHU in 1980. Dr. Pandey also did M.Tech in Heat Power from the same institute in 1987. Prior to joining REC Silchar, Dr. Pandey served in BIT Mesra, Ranchi, as associate lecturer for a period of 3 years

and 6 months. Dr. Pandey did his PhD in mechanical engineering in 1994 from IIT Kanpur. He has published and presented more than 325 papers in international and national journals and conferences. Dr. Pandey has also served in Colombo Plan Staff College Manila, Philippines, in the year 2002 as facul

ty consultant seconded by Government of India. Currently, he is working as professor in department of mechanical engineering of National Institute of Technology, Silchar, Assam, India. He has also served the department in the capacity of head for two terms of 3 years. He has also served as member of

Board of Governors of BIT Silchar for two terms. His research interest areas are combustion, high speed flows, technical education, heat transfer, internal combustion engines, human resource management, gas dynamics and numerical simulations in CFD area from commercial softwares. Dr. Pandey has got

more than 70 SCI-indexed journal papers and more than 150 research articles are indexed in Scopus. His h-index in Scopus is 17; and 23 in google scholar. He has guided 14 students for PhD and 89 students for M.Tech so far.Prof. R.D. Misra received his B.E. in Mechanical Engineering from Jorhat Engi

neering College under Dibrugarh University in 1991, M.Tech. in Energy Studies from Indian Institute of Technology Delhi in 1996, and Ph. D. in Thermal Engineering from Indian Institute of Technology Roorkee in 2004. He has joined as faculty in Mechanical Engineering in the National Institute of Tech

nology Silchar in 1992. He has served NIT Silchar as Lecturer from 1992 to 2003, as Assistant /Associate Professor from 2004 to 2009, as Professor from 2010 to 2018 and as Professor (HAG) from 2018 till date. He has published around 40 papers in referred international journals. Presently He is a pro

fessional member (life) of the Indian Society for Technical Education and The Institute of Engineers (Fellow).Prof. P.K. Patowari is currently a professor at the Department of Mechanical Engineering, National Institute of Technology Silchar, Assam. He obtained his B.Tech degree (Mechanical) from NER

IST, Itanagar, and M.E. (Prod.) from Jadavpur University, Kolkata, and Ph.D. from the Indian Institute of Technology, Kharagpur. His major areas of research interests include Advanced/Non-traditional Manufacturing Processes Micro-Manufacturing, Computer Aided Manufacturing (CAM), Computer Numerical

Control (CNC), Micro Electro Mechanical Systems (MEMS). He has published more than 30 papers in referred international journals. Currently, he is the life member of professional bodies like Indian Society for Technical Education (ISTE) and Institute of Smart Structures and Systems (ISSS) and The Ins

titute of Engineers (Fellow).Prof. Uday Shanker Dixit received his bachelor’s degree in mechanical engineering from the erstwhile University of Roorkee (now Indian Institute of Technology (IIT) Roorkee) in 1987, his M.Tech degree in mechanical engineering from IIT Kanpur in 1993, and his PhD in mech

anical engineering from IIT Kanpur in 1998. He has worked in two industries--HMT, Pinjore, and INDOMAG Steel Technology, New Delhi, where his main responsibility was designing various machines. Dr Dixit joined the Department of Mechanical Engineering, IIT Guwahati, in 1998, where he is currently a p

rofessor. He was also the Officiating Director of the Central Institute of Technology, Kokrajhar (February 2014-May 2015). Dr Dixit has been actively engaged in research in various areas of design and manufacturing over the last twenty-five years. He has authored/co-authored 115 journal papers, 109

conference papers, twenty-seven book chapters, and six books on mechanical engineering. He has also co-edited seven books related to manufacturing. He has guest-edited eleven special issues of journals. Presently he is an Associate Editor of the Journal of Institution of Engineers (India), Series C,

and the Regional Editor (Asia) of the International Journal of Mechatronics and Manufacturing Systems. He has guided twelve doctoral and forty-four masters’ students. Dr Dixit has investigated a number of sponsored projects and developed several courses. Presently, he is the Vice-President of the A

IMTDR conference

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探討matriptase及其下游的HGF/c-Met訊息傳遞路徑對胃癌進程的影響

為了解決LIKE COLOMBO 150的問題，作者鄭若涵 這樣論述：

胃癌（gastric cancer, GC）為全球十大癌症之一，其中90%以上為腺癌（adenocarcinoma）。當胃黏膜發炎未治療復原，可能會演變成癌前病變，包括胃部腸化生（intestinal metaplasia, IM）以及異常增生（dysplasia），進而走向癌症的發生。目前胃癌的預後仍然不佳，而癌細胞的生長、侵襲和轉移則是預後的關鍵，許多蛋白水解酶（protease）會在過程中扮演重要的角色。本研究要探討的matriptase為絲胺酸蛋白水解酶，在先前的文獻中指出，在許多癌症中，包括乳癌、大腸癌、前列腺癌、甲狀腺癌等，matriptase的表達以及活化態會增加，而matri

ptase活化後會促進細胞外基質的水解，並且活化肝細胞生長因子（hepatocyte growth factor, HGF）及其接受器c-Met，進而促進癌症的進程；然而matriptase的活性會被抑制蛋白HAI-1所調控，但目前這些蛋白在胃癌中的表現以及調控機制還不是很清楚。因此本研究使用免疫組織染色（immunohistochemistry, IHC）來觀察matriptase、HAI-1以及c-Met在胃癌以及癌前病變中的表現，以及與胃癌細胞株AGS的生長、遷移、侵襲和凋亡的相關性，並且在細胞中加入PI3K抑制劑LY294002、EGFR抑制劑PD153035以及MEK抑制劑PD980

59，來對相關訊號傳遞路徑做進一步的探討。我們的結果發現：（1）與正常的胃黏膜組織相比，total matriptase、活化態matriptase以及c-Met在胃癌組織中表現會增加，而HAI-1在兩者間沒有顯著差異。（2）在胃部腸化生組織中發現，total matriptase、活化態matriptase、HAI-1以及c-met的表達均會增加。（3）活化態matriptase的表現會隨著胃癌進程而逐漸增加；相反的，HAI-1的表現會在癌前病變時顯著增加，並且隨著進程逐漸下降。（4）使用Kaplan-Meier plotter分析胃癌患者生存率發現，在分化不良的胃癌患者中，matripta

se高表達會有較差的生存率。（5）使用CRISPR將胃癌細胞株AGS的matriptase進行knockout後，發現並不會影響細胞的生長，但是會顯著抑制細胞的遷移和侵襲，並且細胞凋亡會增加，從免疫螢光染色的結果也可以看到，ki67的表現在基因剔除後沒有顯著差異，而MMP-9的表現在基因剔除後有明顯的下降。（6）挑選了幾個路徑的抑制劑對AGS細胞處理，結果發現在加入LY294002之後，matriptase的活化會顯著地受到抑制，因此我們認為matriptase的活化與PI3K路徑有關。