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Stud: Architectures of Masculinity

為了解決Landscape design的問題，作者 這樣論述：

Joel Sanders, FAIA is Principal of JSA (Joel Sanders Architect), his LGBTBE-certified, award-winning architecture firm based in New York, as well as MIXdesign, a think tank and design consultancy dedicated to creating inclusive design solutions that meet the needs of people of different ages, gender

s, religions and abilities. Sanders is Professor-in-Practice at Yale School of Architecture where he was Director of Post-Professional Studies from 2015-2021, and the author of three books -- STUD: Architectures of Masculinity, Joel Sanders: Writings and Projects and Groundwork: Between Landscape an

d Architecture. JSA projects have been featured in international exhibitions and the permanent collections of MoMA, SF MoMA, Art Institute of Chicago and the Carnegie Museum of Art. The firm has received six New York Chapter AIA Design Awards, three New York State AIA Design Awards, three Interior D

esign Best of Year Awards, two ALA/IIDA Library Interior Design Awards, and Design Citations from Progressive Architecture.

Landscape design進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Landscape design的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Ralph Johnson: Complete Works

為了解決Landscape design的問題，作者Johnson, Ralph 這樣論述：

- Provides a comprehensive insight into the complete works of global design and innovation by the prolific industry giant, Ralph Johnson from Perkins+Will- Presents a vivid and yielding portrayal of Ralph Johnson's sense of modernism, with informative essays, in-depth conversations and narrative des

criptions of each design- Features several hundred pages of detailed study, rich, full-color photographs, sketches, illustrations and plans - Augments IMAGES' wide collection of monographs on this current master, whose work spans many decadesNOTABLE PROJECTS Shanghai Natural History Museum, Shanghai

, China O'Hare International Airport Terminal, Chicago, Illinois The Johns Hopkins Hospital New Clinical Building, Baltimore, Maryland Tianjin Museum, Tianjin, China Boeing World Headquarters, 100 N Riverside Plaza, Chicago, Illinois Arizona State University--Science and Technology Building 1, Tempe

, Arizona Case Western Reserve University, Tinkham Veale University Center, Cleveland, Ohio Ralph Johnson's work spans a magnificent range of award-winning projects--in terms of both location and program types, with each project being distinct yet consistent in an underlying process and design inten

t. From a residential high-rise in Chicago, to a university in Africa, to a museum in a park in Asia, Johnson's work is environmentally responsible and uniquely suited to the particular needs of the client, climate, and site. The beautifully presented works in this stunning monograph include both bu

ilt and unbuilt projects and their significance is underpinned by Johnson's deep-held respect for humanistic values and his emphasis on process rather than preconceived product, allowing the work to respond to diverse cultures and urban conditions. Johnson is widely acclaimed for the complexity of h

is designs that incorporate dynamism with modern forms that meaningfully consolidate the surrounding urban fabric and identity and landscape contexts. This 600-page monograph is a comprehensive account of Johnson's long career and features striking examples of Johnson's highly detailed illustrations

and renderings, along with rich, full-color photographs to chronicle his impressive folio of work. This distinguished volume sits comfortably in the heady realm of IMAGES' highly anticipated 21st Century Masters series, which celebrates international juggernauts in the fields of architecture and de

sign. Ralph Johnson is a Principal and Global Design Director at Perkins+Will, where he has worked since 1976. He was elected to the College of Fellows of the American Institute of Architects in 1995, and was elected to the National Academy in 2015 - one of the highest honours in American art and

architecture.

探討發展都市農園於改善熱島效應-以旱溪為例

為了解決Landscape design的問題，作者張玟豫 這樣論述：

台灣地狹人稠，人口和產業朝向都市集中的趨勢更為明顯，都市化程度已高達 79.9％。行政院經濟建設委員會所建構的「台灣永續發展指標系統」中也特別區分出都市台灣 (Urban Taiwan) 的體系，足見都市的發展攸關整體環境的永續性。美國亞利桑那州立大學聯合全球各地的大專機構，透過大數據的蒐集，計量倘若全球各城市全面實施都市農業，每年可生產多達1.8億噸糧食，也可以緩解都市熱島效應，本研究針對都市農園之永續發展以旱溪的鳥竹圍公園為例進行設計，藉由台中市政府推行的綠美化政策提升人均綠地面積，針對旱溪周遭綠地與裸地和公園尋找適合的場地，研究工具應用都市設計審議綠化量得降溫有效的計算，對都市熱

島效應的了解，從一個綜觀的角度來檢視都市的發展是否符合環境永續性的要求，包括能源使用、水泥化程度、綠覆率、水循環和空氣污染等。若能在都市閒置土地增加農園，便能為當地帶來糧食生產與經濟效益，易能減緩都市熱島效應。