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Electric Discharge Hybrid-Machining Processes: Fundamentals and Applications

為了解決New Many 125的問題，作者 這樣論述：

Dr. Basil Kuriachen is serving as an Assistant Professor in the Department of Mechanical Engineering, National Institute of Technology Calicut from 2020. His vivacity and dexterity towards abiding commitment to sublime work ethic conferred him with the Ph.D. and M. Tech degrees from NIT Calicut (201

5) and Mahatma Gandhi University, Kottayam (2011), respectively. His resolute research niches are in the field of metal additive manufacturing, micro/nano-machining processes, precision and ultra-precision machining, modeling and analysis in the machining of ＂difficult to machine＂ materials, tribolo

gy of manufacturing processes, nano-tribology, surface coatings, nano-lubricants, advanced machining processes, friction stir welding & processing and surface characterization. He is the principal investigator (PI) for two currently active projects from DST-SERB and ARDB, DRDO, Govt. of India. Excel

lency in academics and research enabled him to be the recipient of several prestigious national awards inclusive of IEI Young Engineers Award 2019-20, SERB-International Travel Fellowship 2017, and Early Career Research Award of DST-SERB 2016. He has organized five GIAN programs (in collaboration wi

th foreign faculties), and is the reviewer for several international peer-reviewed journals of repute associated with various publishing houses such as ASME, Elsevier, Springer, Taylor and Francis, etc. He has to his credit, 86 research publications in international refereed journals and conferences

alongside two filed patents. Presently, he is guiding 6 Ph. D scholars (One thesis submitted) for carrying out research works in the distinct fields of electrical discharge machining assisted alloying, friction stir welding & processing, laser surface texturing and so on. He has organized many nati

onal and state level programs such as conferences (1), short term courses (3), and state level seminars (4) and has participated in 17 short term courses in his career so far. Prof. (Dr) Jose Mathew is Professor (HAG) & HOD (ME) and Ex-Dean (R&C) of the National Institute of Technology Calicut, Kera

la. He received his M. Tech and PhD from IIT Kanpur (1990) and IIT Bombay (1999) respectively. His interests are micro and nano-machining process, precision and ultra-precision machining, modelling and analysis of machining of ’difficult to machine’ materials, etc. He has published more than 125 res

earch papers in international journals and international conferences. Several M. Tech and PhD theses have been completed under his guidance. He also has worked on a number of industry sponsored research and development projects. He was awarded with Best all-round performance award among NITC faculty

during 2005-06 [Instituted by NIT Calicut and was the first award winner], ISTE- Certificate of Achievement 2008 National award (First Prize) for having guided the Best M.Tech. Thesis in Mechanical Engineering for the thesis titled Theoretical and Experimental Investigations on Mechanical Micro Mac

hining (M3) submitted by Sooraj V.S., ISTE - Certificate of Achievement 2012 National award (First Prize) for having guided the Best M.Tech. Thesis in Mechanical Engineering for the thesis titled ＂Multi-Objective Optimization of Process Parameters in Micro drilling Using Vibration Assisted Micro EDM

＂ submitted by Deepak G. Dilip, and DST International Travel Support (full amount) Scheme award for attending ASME International Conference at Chicago, USA during November 2012. Also, he has developed many state of the art research facilities such as DST-FIST sponsored Centre for Precision Measureme

nts and Nanomechanical Testing, Micromachining Centre, Additive Manufacturing Centre, CNC Centre, Sophisticated Instruments Centre, and CAD/CAM Centre, etc.Prof. (Dr.) Uday Shanker Dixit received B.E. degree in Mechanical Engineering from erstwhile University of Roorkee (now Indian Institute of Tech

nology Roorkee) in 1987, M.Tech. degree in Mechanical Engineering from Indian Institute of Technology Kanpur in 1993, and Ph.D. in Mechanical Engineering from IIT Kanpur in 1998. He has worked in two industries-- HMT, Pinjore and INDOMAG Steel Technology, New Delhi, where his main responsibility was

designing various machines. Dr. Dixit joined the Department of Mechanical Engineering, Indian Institute of Technology Guwahati, in 1998, where he is currently a professor. He was also the Officiating Director of Central Institute of Technology, Kokrajhar from February 2014 to May 2015. Dr. Dixit is

actively engaged in research in various areas of design and manufacturing since last 33 years. He has authored/co-authored about 125 journal papers, about 115 conference papers, 31 book chapters and 7 books in mechanical engineering. He has also co-edited 8 books related to manufacturing. Out of th

ese 15 books, two have been published by CRC press. He has guest-edited 11 special issues of journals. Presently he is an Associate Editor of the Journal of Institution of Engineers (India), Series C and Regional Editor Asia of International Journal of Mechatronics and Manufacturing Systems. He has

guided 14 doctoral and 44 masters’ students. Dr. Dixit has investigated a number of sponsored projects and developed several courses. Presently, he is the vice-president of AIMTDR conference.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決New Many 125的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Dog Star

為了解決New Many 125的問題，作者Shepherd, Megan 這樣論述：

Megan Shepherd is a New York Times-bestselling and Carnegie Medal-nominated author. She grew up in her family’s independent bookstore in the Blue Ridge Mountains and is the author of many acclaimed middle grade and young adult novels including The Madman’s Daughter series, The Cage series, The Secre

t Horses of Briar Hill, and the Grim Lovelies series. She now lives and writes on a haunted 125-year-old farm outside Asheville, North Carolina, with her husband and children, two cats, chickens, bees, and an especially scruffy dog. meganshepherd.com

布里斯洛中間體自由基反應機制之理論研究

為了解決New Many 125的問題，作者謝明修 這樣論述：

含氮雜環卡賓（N-heterocyclic carbene）催化之化學反應中，布里斯洛中間體（Breslow intermediate）扮演重要的催化角色。布里斯洛中間體能以親核基（nucleophile）或自由基（radical）之形式參與反應。本論文探討布里斯洛中間體之自由基特性及形成機制（mechanism），其自由基可從氫自由基轉移或直接氧化形成。安息香縮合反應（benzoin condensation）中，布里斯洛中間體將氫原子轉移至苯甲醛（benzaldehyde）以形成自由基，此自由基可結合形成安息香產物，或排除反應之副產物，使其重新進入催化反應。唯此路徑之反應能障高於傳統非自

由基路徑。此研究亦探討四種布里斯洛中間體之不同電子組態的位能面。其中烯醇鹽（enolate）形式能產生偶極束縛態（dipole-bound state），此為產生自由基之新路徑；拉電子基（electron-withdrawing group）以及立體障礙基（bulky groups）可穩定基態。另外，我們亦研究布里斯洛中間體之碎片化（fragmentation）與重組（rearrangement）。布里斯洛中間體之催化反應可能因其碳氮鍵斷裂而中止，形成碎片。我們證實其反應中可以形成自由基，亦可形成離子。反應趨向之路徑與布里斯洛中間體之羥基的質子化型態有關。碎片化反應亦可視為轉酮醇酶（tran

sketolase）中之噻胺（thiamin）催化反應中之副反應；此研究證實轉酮醇酶透過限制布里斯洛中間體之結構與質子化型態，使其碳氮鍵斷裂需更高之反應能量，進而抑制此副反應。