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Hiking Ruins Seldom Seen Southern New England: A Guide to 40 Sites in Massachusetts, Connecticut and Rhode Island

為了解決To do list的問題，作者Kipfer, Barbara Ann,Dr Bellantoni, Nicholas F. 這樣論述：

Dr. Barbara Ann Kipfer is the author of 14,000 things to be happy about (with more than 1.25 million copies in print). She has written more than 80 books and calendars, mostly lists, including 5,203 Things to Do Instead of Looking at Your Phone, Self-Meditation, Instant Karma, 8,789 Words of Wisdom,

and The Wish List (Workman), 4,000 Questions for Getting to Know Anyone and Everyone (Random House), Roget’s International Thesaurus (HarperCollins), and 1,001 Ways to Live Wild, 1,001 Ways to Slow Down, and 1,001 Ways to be Creative (National Geographic), and the forthcoming Hiking is Fundamental

(Falcon Guides). Dr. Kipfer holds a PhD in Archaeology (Greenwich University), a PhD and MPhil in Linguistics (University of Exeter), an MA (Greenwich University) and PhD in Buddhist Studies (Akamai University), and a BS in Physical Education from Valparaiso University. She is the Senior Lexicograph

er of Zeta Global and has worked for companies such as Google, Dictionary.com, General Electric Research, IBM Research, idealab, and WolframAlpha. She is a Registered Professional Archaeologist. Her website is www.thingstobehappyabout.com. Barbara is now an avid hiker and learning new things with ea

ch hike. Dr. Nicholas F. Bellantoni is emeritus Connecticut State Archaeologist and an associate research professor in the Department of Anthropology in the University of Connecticut. He served as the state archaeologist with the Connecticut State Museum of Natural History and Archaeology Center in

the College of Liberal Arts & Sciences at the University of Connecticut. He earned his BA in Anthropology at the Central Connecticut State University and his MA in Anthropology at University of Connecticut. He received his doctorate in Anthropology from UConn in 1987 and was shortly thereafter appoi

nted state archaeologist. He retired from that position in 2014. Dr. Bellantoni is the co-editor of In Remembrance: Archaeology and Death (1997) and has also contributed to journals such as the Journal of Forensic Science, Journal of Archaeological Science, and to the American Journal of Physical An

thropology. He most recently has authored The Long Journeys Home: The Repatriations of Henry ’Opukaha’ia and Albert Afraid of Hawk and And So The Tomb Remained: Exploring Archaeology and forensic Science in Connecticut’s Historical Family Mausolea. He has been excavating in Connecticut for over 40 y

ears.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決To do list的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Oliver and the Night Giants

為了解決To do list的問題，作者O’Meara, Kitty 這樣論述：

What would you do if three giants came to your bedroom window one night and invited you to help them fix the world? That’s exactly what happens to Oliver when he least expects it, in this very special bedtime story. Come along with Oliver and the Night Giants as they explore what happens when we all

ow our imaginations to lead the way!Oliver and the Night Giants begins when three giants appear in Oliver’s bedroom window one evening as he is drifting off to sleep. The giants convince young Oliver, a budding artist, to help them with their nighttime work of repairing the world. Oliver helps the

giants with a long list of nighttime tasks, from brightening the moon to polishing the stars, from adjusting mountains to creating snowflakes, from planting seeds to calming the sea. As he travels the planet and beyond with the Night Giants as an important part of their team. Oliver and the Night G

iants is written in the tradition of a classic children’s literature journey story. This thoughtful, poignant bedtime tale is an homage to the power of the imagination and the significance of valuing one’s dreams, and it is sure to be a favorite with children, families, and teachers. The timeless th

emes and vivid imagery make this story a pleasure to read aloud and for children to read on their own. Kitty O’Meara lives near Madison, Wisconsin, with her husband, Phillip Hagedorn, their five rescue dogs, three cats, gardens, and books. Formerly a middle school writing and literature teacher a

nd hospital and hospice chaplain, she is currently a spiritual director and has been a lifelong writer and artist. She has been called ＂the poet laureate of the pandemic＂ based on her wildly popular, widely circulated, and hopeful poem about the COVID-19 pandemic. That poem is illustrated and presen

ted in book form in And the People Stayed Home, her best-selling first print book, published by Tra Publishing. She is also the author of The Rare, Tiny Flower (Tra Publishing, 2021). PRAISE FOR KITTY O’MEARA ＂Kitty O’Meara is the poet laureate of the pandemic. . . . The poem has become shorthand fo

r a silver-linings perspective during the coronavirus outbreak.＂--O, The Oprah Magazine ＂She has given the world a small piece of joy.＂--BookTrib ＂A communal beacon of hope.＂--The Washington Post ＂She is challenging us to grow--to look inside, to listen deeply, to allow ourselves to think differentl

y, and ultimately, to create new ways of living on the planet.＂--Deepak Chopra, MD, author, Metahuman ＂A stunning and peaceful offering of introspection and hope...＂--The Children’s Book Review ＂O’Meara’s words come to life for future generations to...encourage everyone to find silver linings, think

differently and never lose hope.＂--B & N Reads Born in Genoa, illustrator Anna Pirolli moved to Milan to study illustration at the European Institute of Design, where she graduated in 2001. She has worked as a freelance illustrator and art director for companies such as Mondadori, Pearson, Vogue, M

TV, Kinder Ferrero, Telecom, Nickelodeon, Furla, Zecchino d’oro, Disney, following the creative process from concept to creation. She’s also a visiting professor at the Accademia di Brera in Milan, where she teaches design applied to the arts. Despite her love for traditional techniques, her artwork

is mostly digital. Ironically, her dream-like, suspended atmospheres often don’t look digital at all. Her first picture book, I Hate My Cats, written by Davide Calì, was published by Chronicle Books, and the illustrations from her latest book, Anonymouse by Vikki VanSickle (Tundra Books) won the Di

lys Evans Founder’s Award in the 2021 Society of Illustrators The Original Art Show.

觀光夜市攤商對行動支付持續使用意願之研究

為了解決To do list的問題，作者陳姿羽 這樣論述：

近年來，由於全球網路及科技的普及化，已經從現金或信用卡交易發展到行動支付。多元化的支付已是現今交易趨勢，行動支付儼然成為消費大眾生活中的一部分。只需透過智慧型手機，就能利用行動條碼或QR Code給予店家輕鬆付款。 在夜市攤商支援多元付費管道的前提下，將有望提升行動支付使用率，過去較少以夜市攤商使用行動支付角度切入之相關研究，故為本研究動機之一。本研究以寧夏夜市商圈中取樣已使用行動支付裝置的攤商作為研究對象，蒐集相關寧夏夜市及臺灣夜市的報章雜誌、國內外論文、網路資料，並分析整理多篇行動支付相關文獻與店家初訪資料，完成本研究的模型建構與問卷設計。利用SPSS統計軟體進行樣本分析法

來驗證各項研究假設，根據實證結果發現在「感知有用性」、「感知易用性」、「供應商特質」、「消費者意願」會影響使用意願，而「感知風險與成本」、「政府推廣」則不影響使用意願。