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Hiking Ruins Seldom Seen Southern New England: A Guide to 40 Sites in Massachusetts, Connecticut and Rhode Island

為了解決bs的問題，作者Kipfer, Barbara Ann,Dr Bellantoni, Nicholas F. 這樣論述：

Dr. Barbara Ann Kipfer is the author of 14,000 things to be happy about (with more than 1.25 million copies in print). She has written more than 80 books and calendars, mostly lists, including 5,203 Things to Do Instead of Looking at Your Phone, Self-Meditation, Instant Karma, 8,789 Words of Wisdom,

and The Wish List (Workman), 4,000 Questions for Getting to Know Anyone and Everyone (Random House), Roget’s International Thesaurus (HarperCollins), and 1,001 Ways to Live Wild, 1,001 Ways to Slow Down, and 1,001 Ways to be Creative (National Geographic), and the forthcoming Hiking is Fundamental

(Falcon Guides). Dr. Kipfer holds a PhD in Archaeology (Greenwich University), a PhD and MPhil in Linguistics (University of Exeter), an MA (Greenwich University) and PhD in Buddhist Studies (Akamai University), and a BS in Physical Education from Valparaiso University. She is the Senior Lexicograph

er of Zeta Global and has worked for companies such as Google, Dictionary.com, General Electric Research, IBM Research, idealab, and WolframAlpha. She is a Registered Professional Archaeologist. Her website is www.thingstobehappyabout.com. Barbara is now an avid hiker and learning new things with ea

ch hike. Dr. Nicholas F. Bellantoni is emeritus Connecticut State Archaeologist and an associate research professor in the Department of Anthropology in the University of Connecticut. He served as the state archaeologist with the Connecticut State Museum of Natural History and Archaeology Center in

the College of Liberal Arts & Sciences at the University of Connecticut. He earned his BA in Anthropology at the Central Connecticut State University and his MA in Anthropology at University of Connecticut. He received his doctorate in Anthropology from UConn in 1987 and was shortly thereafter appoi

nted state archaeologist. He retired from that position in 2014. Dr. Bellantoni is the co-editor of In Remembrance: Archaeology and Death (1997) and has also contributed to journals such as the Journal of Forensic Science, Journal of Archaeological Science, and to the American Journal of Physical An

thropology. He most recently has authored The Long Journeys Home: The Repatriations of Henry ’Opukaha’ia and Albert Afraid of Hawk and And So The Tomb Remained: Exploring Archaeology and forensic Science in Connecticut’s Historical Family Mausolea. He has been excavating in Connecticut for over 40 y

ears.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決bs的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Viral and Antiviral Nanomaterials: Synthesis, Properties, Characterization, and Application

為了解決bs的問題，作者 這樣論述：

Devarajan Thangadurai, PhD, is Assistant Professor at Karnatak University, Dharwad in India and did his postdoctoral research at the University of Madeira, Portugal, University of Delhi, India, and ICAR National Research Centre for Banana, India. He is the recipient of Best Young Scientist Award wit

h Gold Medal from Acharya Nagarjuna University, India, and the VGST-SMYSR Young Scientist Award of the Government of Karnataka, India. He has interest and expertise in the fields of biotechnology and nanotechnology for sustainable future. He has authored/edited more than twenty five books with inter

national publishers in USA, Canada, Switzerland and India. He has authored/coauthored 210 publications inclusive of journal articles, book chapters, books and invited presentations. He has extensively travelled to many universities and institutes in Africa, Europe and Asia for academic works, scient

ific meetings, and international collaborations. Saher Islam, PhD, is an HEC Scholar (Higher Education Commission) of the Islamic Republic of Pakistan at the University of Veterinary and Animal Sciences, Lahore, where she received her BS, MPhil and PhD in Molecular Biology, Biotechnology and Bioinfo

rmatics. She is IRSIP Scholar at Cornell University, New York and Visiting Scholar at West Virginia State University, West Virginia in USA. She has keen research interests in genetics, molecular biology, biotechnology, and bioinformatics pertaining to animal, dairy and food science, and has ample ha

nds on experience in molecular marker analysis, whole genome sequencing and RNA sequencing. She has visited USA, UK, Singapore, Germany, Italy and Russia for academic and scientific trainings, courses, and meetings. She is the recipient of 2016 Boehringer Ingelheim Fonds Travel Grant from European M

olecular Biology Laboratory, Germany. She is an author/coauthor of 50 publications including journal articles, book chapters, books and conference presentations. Charles Oluwaseun Adetunji, PhD, is presently the Ag. Director of Intellectual Properties and Technology Transfer; Chairman Committee on R

esearch Grant and Associate Professor of Microbiology and Biotechnology at EUI. He has won several scientific awards and grants from renowned academic bodies like Council of Scientific and Industrial Research (CSIR) India, and Department of Biotechnology (DBT) India, The World Academy of Science (TW

AS) Italy, Netherlands Fellowship Programme (NPF) Netherlands, The Agency for International Development Cooperation Israel, Royal Academy of Engineering UK among many others. He has filed several scientific patents on nanobiosurfactants, nanobiopesticdes and many more. He has published over 150 scie

ntific journals and conference proceedings in international and local refereed journals. His research interest includes microbiology, biotechnology, post-harvest management, and nanotechnology. He is an editorial board member of many international journals and serves as a reviewer to many double-bli

nd peer review journals of Elsevier, Springer, Taylor and Francis, Wiley, PLOS One, Nature, American Chemistry Society, Bentham Science Publishers etc. He is a member of many scientific and professional bodies like American Society for Microbiology, Nigerian Young Academy, Biotechnology Society of N

igeria, and Nigerian Society for Microbiology. He has won international recognition and also acted as a keynote speaker delivering invited talk/position paper at various universities, research institutes and several centers of excellence which span across several continent of the globe. He has over

the last fifteen years built strong working collaborations with reputable research groups in numerous and leading Universities across the globe. He is the convener for Recent Advances in Biotechnology, which is an annual international conference where renowned microbiologists and biotechnologists co

me together to share their latest discoveries. He is also the Founder & CEO of BECTIK Biotechnology and Nanotechnology Company.

布拉姆斯《大學慶典序曲》與《悲劇序曲》之探究與指揮詮釋

為了解決bs的問題，作者郭愛丹 這樣論述：

德國浪漫樂派作曲家布拉姆斯（Johannes Brahms, 1833-1879），與巴赫 （Johann Sebastian Bach, 1685-1750）、貝多芬（Ludwig van Beethoven, 1770-1827）被德國音樂家畢羅（Hans von Bülow, 1830-1894）譽為 「德國三B」。布拉姆斯作品常運用古典樂派嚴謹莊重的音樂形式，融入浪漫樂派寬廣且極富情感的旋律色彩，以及大量「對位」、「模進」、「發展變奏」等創作手法，呈現深沈繁厚的音響織度。作品中高度連貫性、豐富厚重音響效果、具民謠風格旋律特徵等，展現出布拉姆斯除了「具保守樂派的古典主義者」，還融匯古典

與浪漫之精髓，進而走出屬於他個人獨特的風格。布拉姆斯創作涵蓋鋼琴曲、交響曲、室內樂及藝術歌曲等，而管弦樂序曲終其一生僅完成兩部：《大學慶典序曲》（Academic Festival Overture）和《悲劇序曲》（Tragic Overture）。這兩首作品皆為同一年完成，音樂情感性質卻截然不同。《大學慶典序曲》主要運用當時德國學生數首校園歌曲為題材彙編而成，描繪莘莘學子朝氣蓬勃的青春活力；《悲劇序曲》採用悲劇性格強烈的d小調，使用嚴謹奏鳴曲式結構創作。本論文共分為五章。第一章為研究目的、範圍及方法之撰寫；第二章概述作曲家生平、時代風格與序曲概論；第三章與第四章分別論述《大學慶典序曲》及《悲

劇序曲》創作背景、樂曲分析、指揮詮釋及有聲資料之速度與音色探討；第五章為結論。藉由兩部管弦樂作品探討與研究、樂團演練實踐等，深入剖析作曲家傳遞的音樂言語，達到作品真實且完整的詮釋。