modulation醫學的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列包括價格和評價等資訊懶人包

Vaccine Efficacy Evaluation: The Gnotobiotic Pig Model

為了解決modulation醫學的問題，作者Yuan, Lijuan 這樣論述：

Lijuan Yuan is a Professor of Virology and Immunology in the Virginia-Maryland Vet Med’s Department of Biomedical Sciences & Pathobiology. Dr. Yuan studies the interactions between enteric viruses and the host immune system. Her lab’s research interests are focused on pathogenesis and innate and ada

ptive immune responses induced by enteric viruses, especially noroviruses and rotaviruses, and on the development of safer and more effective vaccines against viral gastroenteritis. One of the major research efforts of the Yuan lab is to study mechanisms of immune modulation by probiotic bacteria, p

rebiotics (rice bran) and human gut microbiota in rotavirus and norovirus infection and vaccination. These studies utilize wild type, gene knock-out and human gut microbiota transplanted gnotobiotic pig models of human rotavirus and norovirus infection and diseases and cell culture model of rotaviru

s infection. Currently, the Yuan lab is evaluating the immunogenicity and protective efficacy of several candidate rotavirus and norovirus vaccines. See: http: //www.vetmed.vt.edu/research/labs/yuan/

Probiotic Research in Therapeutics: Volume 2: Modulation of Gut Flora: Management of Inflammation and Infection Related Gut Etio

為了解決modulation醫學的問題，作者 這樣論述：

Chapter 1: Gut bacterial dysbiosis and its clinical implications.- Chapter 2: Probiotic based interventions for improving intestinal health.- Chapter 3: Probiotics in the prevention of infant infection.- Chapter 4: Animal models for probiotic interventions under gut inflammatory conditions.- Chap

ter 5: Probiotics as anti-inflammatory agents in inflammatory bowel disease and irritable bowel syndrome.- Chapter 6: Antibiotic associated diarrhea and update on probiotics recommendations.- Chapter 7: Potential correlation between homeostasis control and tumour microenvironment regulation of probi

otic as a therapeutic agent to manage gastrointestinal cancer.- Chapter 8: An update on the probiotic usage in bacterial vaginosis.- Chapter 9: Indigenous probiotic lactobacillus stains to combat gastric pathogen Helicobacter pylori: Microbial interference therapy.- Chapter 10: Designing probiotics

and its clinical applications.- Chapter 11: Probiotic interventions for oral health.- Chapter 12: Probiotics targeting enteric infections.- Chapter 13: Probiotics for allergic airway infection and inflammations.- Chapter 14: Probiotics as edible vaccines.- Chapter 15: Probiotics for atopic dermatiti

s.

潛藏危機：Musashi-1固有無序區域介導與神經退行性疾病相關蛋白之異常聚集

為了解決modulation醫學的問題，作者杜岱芸 這樣論述：

蛋白質病變(proteopathy)是退行性疾病的常見原因，通過錯誤折疊的蛋白質異常聚集形成類澱粉沉積症(amyloidogenesis)，從而導致破壞組織內的穩態。尤其是，近期研究表明細胞內具有固有無序區域 (intrinsically disordered regions)的蛋白容易進行液-液相分離(liquid-liquid phase separation)，從而在細胞中組裝蛋白質凝聚層(coacervates)。在本研究中，我們假設具有固有無序區域的蛋白質受環境壓力影響，促進異常折疊甚至形成聚集體，這將進一步形成澱粉樣斑塊(amyloid plaques)並在組織內堆積，導致蛋白質

病變。我們主要探討不僅是RNA結合蛋白、也是幹性基因的Musashi-1，是否與具有豐富IDR的Musashi-1 C-末端區域相互作用以進行液-液相分離，最終形成澱粉樣原纖維(amyloid fibrils)。為了確認哪些序列更易於形成澱粉樣蛋白，因此對Musashi-1的C-末端進行了序列連續刪除來取得不同長度的片段。我們的研究結果表明Musashi-1 C-末端面對不同pH值和鹽濃度會影響液-液相分離狀態，包含改變蛋白質相分離的出現時間、形狀和大小，隨著時間的推移，Musashi-1 C-末端也可以形成澱粉樣蛋白原纖維。而當在氧化壓力下，它會在細胞內誘導組裝應激顆粒與不可逆的聚集體的形成

，另一方面，當細胞同時表達Musashi-1 C-末端和內源性TDP-43，Musashi-1 C-末端誘導TDP-43從細胞核錯誤定位到細胞質。此外，Musashi-1 C-末端促進磷酸化和泛素化TDP-43。總結來說，我們提出了關於Musashi-1與神經退行性疾病相關蛋白相互作用導致異常聚集的新見解，這些發現有助於提供解決退行性疾病的新思路。