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Osteoarthritis Health Professional Training Manual

為了解決oa的問題，作者 這樣論述：

Osteoarthritis Health Professional Training Manual addresses current gaps in knowledge and the skills and confidence that are necessary to deliver evidence-based OA care that is consistent with international guidelines and for effective translation to clinical practice for health professionals. W

ritten for health care professionals that meet patients with osteoarthritis in the clinic, like GPs, physiotherapists, rheumatologists, orthopedic surgeons, and MDs and PTs in training, medical students and basic researchers on osteoarthritis who want an update on the clinical aspects of OA, this bo

ok addresses the urgent need to improve health professional knowledge in managing patients with osteoarthritis.

oa進入發燒排行的影片

海洋酸化對點帶石斑仔稚魚鈣離子運輸以及骨骼鈣化作用的影響

為了解決oa的問題，作者黃辰宏 這樣論述：

根據政府間氣候變化專門委員會（IPCC）的預測，在本世紀末，二氧化碳濃度將提升至500~900 µatm，海水的酸鹼值則下降至7.9~7.7。海洋酸化會造成海水中碳酸鈣（CaCO3）飽和濃度升高，不利碳酸鈣在海水當中產生固態沉澱，並影響貝類以及珊瑚外骨骼的形成。此外，水體酸化可能會影響硬骨魚類的離子調節與發育生長，但並不清楚水體酸化是如何影響海洋硬骨魚類鈣離子的調節恆定性。本實驗比較飼養於正常的海水（pH 8.1）及不同酸化程度的海水（pH 7.8 與 pH 7.4）中40日齡點帶石斑仔稚魚，鈣離子運輸蛋白以及骨骼鈣質代謝相關基因在發育過程中的表現量變化。整體而言，實驗發現在酸化的環境之下仔

稚魚的成長與骨骼鈣離子累積並不會受到影響。然而，根據仔稚魚的離子調節、骨骼形成與鈣離子累積等數據的主成分分析卻顯示，水體酸化會影響整體的離子調節能力發展，以及可能輕微地影響對骨骼鈣離子沉積與再吸收。但是，若是以單一因子或以線性回歸進行分析與比較，則難以界定酸化對任何一組離子調控相關基因，例如細胞基底膜的鈣離子幫浦（pmca）、上皮鈣離子通道（ecac）以及運輸能量來源的鈉鉀離子幫浦基因的直接影響。此外，與骨骼鈣質沉積相關的成骨細胞（bglap）及破骨細胞（ctsk and trap）在海水酸化得情況下也並無獨立的顯著差異。實驗雖然表明在高二氧化碳的水體中，pH下降可能造成仔稚魚離子調節、骨骼形

成與鈣離子累積等因子的相互作用，而導致整體的生理差異。本研究亦顯示，點帶石斑魚仔稚魚的生長對高度酸化條件並不敏感，但此研究不能排除未來海洋酸化對沿海海水中的水產養殖業和野生種群影響的可能性。以目前而言，在海洋酸化的情況之下，硬骨魚的離子調節與鈣離子平衡的調節機制尚不明朗，須待更多研究證明。

Polysaccharides of Microbial Origin: Biomedical Applications

為了解決oa的問題，作者 這樣論述：

Dr. Joaquim Miguel Oliveira (0000-0001-7052-8837), BSc, PhD (Portuguese, M, 41 years old) is a Principal Investigator ＂Investigador FCT 2012 and Investigador FCT 2015＂ at the PT Government Associate Laboratory ICVS/3B’s. He is the Vice President of I3Bs - Institute 3B’s (Univ. Minho) and Director o

f Pre-Clinical Research at the FIFA MEDICAL CENTER, Estádio do Dragão, Porto, PT since Feb. 2013 and Pro-Director of the 3B’s Research Group, Univ. Minho, PT. Currently, he is a Lecturer in Doctoral Program in Tissue Engineering, Regenerative Medicine and Stem Cells (TERM&SC) at UMinho, PT (since De

c. 2013). He is also an Invited lecturer at the Faculty of Medicine, U. Porto (since Sept. 2013) and Dept. of Polymer Eng., UM, PT (2009-present). Along the years he has focused his work on the field of biomaterials for tissue engineering, nanomedicine, stem cells and cell/drug delivery. More recent

ly, he set-up a new research line within the ICVS/3B’s on 3D in vitro models for cancer research.Dr. Hajer Radhouani (0000-0003-1007-4073), MsC, PhD (Tunisian/Belgian/Portuguese, F, 37 years old), is a postdoctoral researcher at the Portuguese Government Associate Laboratory ICVS/3B’s, University of

Minho. She has been working with biomaterials based on natural polysaccharides to treat different articular cartilage pathologies. She has been awarded with grants and funds that allow to develop a new biomaterial as a potential candidate for tissue engineering applications. Currently, she is worki

ng on Kefiran polymer as a novel therapy for OA treatment. She published 51 publications listed in ISI Web of Knowledge, 3 international granted patents and 3 book chapters, among others; having a Scopus h-index of 17 and more than 834 citations. She also presented more than 100 works (posters and o

ral presentations) in conferences and meetings.Prof. Rui L. Reis (0000-0002-4295-6129), DSc, Hon. Causa MD, Hon. Causa PhD, FBSE, FTERM, member NAE (USA), FAIMBE, FEAMBES is a Full Professor of Tissue Engineering, Regenerative Medicine, Biomaterials and Stem Cells at University of Minho (UMinho). He

is, since 2013, the Vice-Rector/Vice-President for Research and Innovation of the University of Minho, Braga & Guimarães, Portugal. He is also the Director of the 3B’s Research Group, part of the I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of the UMinho in Portugal, an

d the Director of the PT Government Associate Laboratory ICVS/3B´s.

銀行市場紀律與資訊揭露對盈餘平滑的影響

為了解決oa的問題，作者李國賓 這樣論述：

本研究採用2008至2013年間全球的商業銀行為研究樣本，探討市場紀律和資訊揭露對銀行盈餘平滑所產生的影響，所以使用86個國家，765家商業銀行為樣本，樣本總數為4590項。主要結論有三項：(1)整體銀行產業來說，銀行對於同業拆款率的揭露較為重視，當整體銀行同業拆款率揭露越多，會減少盈餘管理的使用。(2)不管銀行規模大小，對於同業拆款率的揭露，不受整體銀行規模大小的影響。 (3)對於已開發國家的銀行而言，對於資訊揭露指數較為重視，開發中國家的銀行則是對於同業拆款率的揭露較為重視。