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Skill: The Making of Modern Civilization

為了解決Major的問題，作者Greenhalgh, Paul 這樣論述：

Paul Greenhalgh is internationally renowned as an historian of art, design and the decorative arts. He is currently director of the Sainsbury Centre for the Visual Arts, one of the UK’s principal institutions for the study and display of art. Prior to this he held a number of senior roles in several

different countries, including head of research at the V&A Museum, director and president of the Corcoran Gallery of Art and College of Art and Design (USA), and President of NSCAD University (Canada). He has lectured and taught in leading organisations all over the world. Since returning to the UK

in 2010, he has been invited by major institutions and the UK government to fill a number of national roles, including chair of the Research Excellence Framework (REF) for Art and Design and Art History, and chair of the Arts Advisory Committee of the University of Edinburgh. He is a senior honorar

y research fellow at the V&A Museum.

Major進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Major的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Essays on Aristotle’s Eudemian Ethics

為了解決Major的問題，作者Heinaman, Robert (EDT) 這樣論述：

Two major works on ethics have come down to us under Aristotle's name, the Nicomachean Ethics and the Eudemian Ethics, but, quite unjustifiably, the Eudemian Ethics has been largely neglected by students of ancient philosophy. This important collection of essays from the sixth Keeling colloquium on

ancient philosophy tries to rectify this one-sided approach to Aristotle's ethics by focusing on the positions and arguments of the Eudemian Ethics. As the essays demonstrate, Aristotle's views in the Eudemian Ethics frequently differ in interesting and surprising ways from those found in the Nicoma

chean Ethics and deserve study for their own sake, not merely for purposes of comparison with the Nicomachean Ethics. The contributors include some of the best known Aristotle scholars of the present day. Christopher Rowe and Jennifer Whiting investigate the Eudemian Ethics' account of friendship (p

hilia) while M.M. McCabe examines the closely related issue of self-knowledge in EE VII.12. Stephen White analyzes the Eudemian Ethics' account of eudaimonia, David Charles focuses on voluntary action, and Friedemann Buddensiek investigates Aristotle's difficult discussion of good fortune (eutuchia)

in EE VIII.2. The volume also contains critical discussions of these papers provided by commentators, who, along with Whiting and McCabe, include Julia Annas and Sarah Broadie. Dr Robert Heinaman, Reader in Philosophy, University College London, UK

中國大陸滾裝貨輪對台灣防衛系統策略運用模式之影響

為了解決Major的問題，作者吳振安 這樣論述：

自 1949 年以來，中國大陸從不曾放棄以武力犯台作為完成統一大業的手段之一，並持續強化軍事整備及灰色地帶行為襲擾，對我國防安全威脅與日俱增，包含近年逐步 推動國防建設，與自2015年開始的軍事改革，至2020年已基本完成軍隊領導指揮體制、部隊兵力結構改革，期在 2035年達成基本實現國防和軍隊現代化，並且具備對臺灣作戰優勢及抗衡外軍能力，以對我國防衛安全造成嚴峻之挑戰。中國大陸過去一直以來無 法突破載運大量重型武器裝備與武裝人員的運輸能力，但是至2017年始，中國大陸已透過軍管民用船舶-滾裝貨輪來突破無法載運大量裝備與人員之窘境，達成大量投送貨 物與人，裝穿越台灣海峽之目的。依中國大陸之中

華人民共和國國防動員法規定，國家決定實施國防動員後，儲備物資無法及時滿足動員所需，縣級以上的中國大陸政府單位可以依法對民用資源進行徵用，而且預估將超過 37 餘艘以上具有大量運輸能力之滾裝貨輪，可能被徵收軍用。自2019年以來多次的中國大陸大型軍演，皆可看見軍管民用之滾裝貨輪接受徵用於載運重裝備的身影，且部分經改裝之滾裝船可運載至????50輛ZTD-05兩棲突擊車，其大量運載能力，已對我國防衛作戰構成相當程度之威脅。台灣本島國際港口計有五處，其中以高雄港、臺中港與臺北港碼頭數量較多、港區腹地較大且聯外道路較為完整，若遭敵奪佔，並使用各類型滾貨完成武器裝備及武裝人 員之儰裝卸貨，將對我國安全防

衛造成重大影響。本文即針對中國滾裝貨輪發展現況、軍用演訓運用及對我國西部國際港口之威脅，利用情境模式分析、SWOT 與 TOWS策略分析，並整合情監偵手段、強化先期制海能力與完備固封守港等作為，以剖析對我防衛系統之影響，並提出整合現有地面軍力與情資、對敵航母進行制壓、鞏固與開拓軍購市場、善用守勢之利持續戰場經營、持續鞏固國際關係等重要攻略，以及整合情監偵手 段盡早預警、加強避戰、完備封毀港作為等重要防守策略，可供我軍採用及應對，俾利防範中國解放軍可能採取之軍事威脅活動，提高我軍作戰之成功機會。關鍵詞:滾裝貨輪、中國動員法、國際港、防衛系統、SWOT 策略分析