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Courageous: 10 Strategies for Thriving in a Hostile World

為了解決Pathway的問題，作者Jeffress, Robert 這樣論述：

Dr. Robert Jeffress is senior pastor of the 14,000-member First Baptist Church in Dallas, Texas, and is a Fox News contributor. His daily radio program, Pathway to Victory, is heard on more than 900 stations nationwide, and his weekly television program is seen on thousands of cable systems and stat

ions in the United States and in 195 countries around the world. Known for his bold, biblical stands on cultural issues, Jeffress has been interviewed on more than 3,000 radio and TV programs, including Good Morning America, CBS This Morning, Fox & Friends, MSNBC, CNN, Real Time with Bill Maher, and

Hardball with Chris Matthews. He is the author of Not All Roads Lead to Heaven, A Place Called Heaven, and Choosing the Extraordinary Life. He lives in Dallas.

Pathway進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Pathway的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Your Body in Balance: The New Science of Food, Hormones, and Health

為了解決Pathway的問題，作者Barnard, Neal D. 這樣論述：

Now in paperback, this nationally bestselling book explains the shocking new science of how hormones are wreaking havoc on the body, and the delicious solution that improves health, reduces pain, and even helps to shed weight. Hidden in everyday foods are the causes of a surprising range of healt

h problems: infertility, menstrual cramps, weight gain, hair loss, breast and prostate cancer, hot flashes, and much more. All of these conditions have one thing in common: they are fueled by hormones that are hiding in foods or are influenced by the foods we eat. Your Body in Balance provides step-

by-step guidance for understanding what’s at the root of your suffering-and what you can do to feel better fast. Few people realize that a simple food prescription can help you tackle all these and more by gently restoring your hormone balance, with benefits rivaling medications. Neal Barnard, MD, a

leading authority on nutrition and health, offers insight into how dietary changes can alleviate years of stress, pain, and illness. What’s more, he also provides delicious and easy-to-make hormone-balancing recipes, including: Cauliflower Buffalo Chowder Kung Pao Lettuce Wraps Butternut Breakfa

st Tacos Mediterranean Croquettes Apple Pie Nachos Brownie Batter Hummus Your Body in Balance gives new hope for people struggling with health issues. Thousands of people have already reclaimed their lives and their health through the strategic dietary changes described in this book. Whether you’

re looking to treat a specific ailment or are in search of better overall health, Dr. Neal Barnard provides an easy pathway toward pain relief, weight control, and a lifetime of good health.

以網紅作為周邊線索對產品態度及購買意願之研究

為了解決Pathway的問題，作者鄭雁庭 這樣論述：

因應新冠疫情，網路購物的需求越來越高，而美妝保養品的網路購物市場也 越來越成熟，消費者在網路上購買美妝保養品的意願也越來越高而現行的網路行 銷方式越來越多。而現行的網路行銷的方法很多樣化，本研究試圖以推敲可能性 理論模型來研究探討當有網紅或是KOL介入作為周邊線索時，會如何影響消費者 的廣告態度以及購買意願。網紅或是KOL的影響力是否會影響高涉入及低涉入消 費者的廣告態度及購買意願呢? 本研究採用問卷調查法，發放時間為2022年6月3日至2022年6月16日，以 Instagram的限時動態廣告作為廣告曝光的媒介，利用新創保養品品牌-影響因子 的精華液作為操弄產品，使用推敲可能性理論模

型作為研究方法來分析中央路徑 及周邊路徑對於高涉入和低涉入消費者的交互作用及影響。先以測試問卷測量出 強論點品質及弱論點品質後，在正式問卷合作三位網紅作為周邊路徑的網紅代 言，共發放問卷445份，回收篩選有效問卷385份。問卷調查完後有連結可以連到 品牌的官方網站進行下單，而最後分析實際轉換效果。 本研究採用SPSS統計軟體進行敘述性統計分析、信度分析、Bartlett的球形檢 定、總變異量分析、變異數分析、迴歸分析。結果顯示:高涉入受試者在接收強 論點品質的訊息時廣告態度的合意度會比弱論點品質高，但購買意願沒有顯著的 差別;低涉入受試者對於網紅代言的產品廣告態度沒有顯著性的差別，但購買意

願卻是有顯著性地高;當有周邊路徑的網紅代言時能夠提高購買意願。在實際轉換的數據顯示，實際下單購買的低購買意願消費者，皆受到網紅代 言的影響。而下單率最高的模組是接收到好的廣告論點品質的高涉入受試者，因 此品牌在操弄廣告時，可以考慮下單率最高的這個模組，針對高涉入的消費者給 予好的廣告內容來增加購買意願。