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Therapeutic Efficacy of Alpinumisoflavone on Prostate Cancer cells via Repressing AR and Targeting FASN-mediated Lipid Biosynthesis

為了解決R68的問題，作者Phakkhathorn Ruangsai 這樣論述：

Prostate cancer (PCa) is the most ordinary cancerous in men, which has been mainly noticed in Western and Asian countries including Taiwan. The aggregation of PCa and castration-resistant PCa aggressiveness have been the crucial causes in patient’s mortality. To seek new therapeutic strategies to c

ure this lethal progression is an urgent need. In this study, we endeavored to investigate the therapeutic efficacy of alpinumisoflavone (AIF) on PCa cells, including LNCaP (androgen-dependent) and C4-2 (castration-resistant) PCa cell lines. In the results of an investigation, AIF exhibited the atte

nuation of cell proliferation, migration, and invasion in both LNCaP and C4-2 cells. Furthermore, AIF enabled to reduce the expression of androgen receptor (AR) and prostate-specific antigen (PSA) as well as inhibit the expression of fatty acid synthase (FASN), a rate-limiting factor for de novo lip

id biosynthesis (lipogenesis). By inhibiting FASN expression, AIF significantly decreased the intracellular fatty acid amounts and lipid droplet accumulation in PCa cells. Moreover, through co-targeting FASN-mediated lipogenesis and the AR axis, AIF induced the caspase-dependent apoptotic pathway in

LNCaP and C4-2 cells. In summary, our data demonstrated for the first time the potential of AIF as a novel therapeutic compound and provide an alternative opportunity for the treatment of patients with PCa malignancy.