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Function Spaces, 2

為了解決Suzuki USA的問題，作者Pick, Lubos,Musil, Vit,Kufner, Alois 這樣論述：

The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to mak

e available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research a

t the crossroads of these areas are particularly welcome. Editor-in-ChiefJürgen Appell, Würzburg, Germany Honorary and Advisory EditorsCatherine Bandle, Basel, SwitzerlandAvner Friedman, Columbus, Ohio, USAManuel del Pino, Bath, UK, and Santiago, ChileMikio Kato, Nagano, JapanWojciech Kryszewski, To

ruń, PolandVicenţiu D. Rădulescu, Kraków, PolandSimeon Reich, Haifa, Israel Please submit book proposals to Jürgen Appell. Titles in planning includeIreneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020)Cyril Tintarev, Profile Decompositio

ns and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020)Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

Suzuki USA進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Suzuki USA的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Function Spaces, 1

為了解決Suzuki USA的問題，作者Pick, Lubos,Musil, Vit,Kufner, Alois 這樣論述：

The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to mak

e available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research a

t the crossroads of these areas are particularly welcome. Editor-in-ChiefJürgen Appell, Würzburg, Germany Honorary and Advisory EditorsCatherine Bandle, Basel, SwitzerlandAvner Friedman, Columbus, Ohio, USAManuel del Pino, Bath, UK, and Santiago, ChileMikio Kato, Nagano, JapanWojciech Kryszewski, To

ruń, PolandVicenţiu D. Rădulescu, Kraków, PolandSimeon Reich, Haifa, Israel Please submit book proposals to Jürgen Appell. Titles in planning includeIreneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020)Cyril Tintarev, Profile Decompositio

ns and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020)Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

有限元素法模擬醫療元件周圍之細胞行為：以骨釘與水膠為例

為了解決Suzuki USA的問題，作者鄭厚雍 這樣論述：

近年來，牙釘和水膠在臨床醫療上被廣泛地研究與討論，故本論文選擇這兩種醫療元件作為研究對象。(1) 牙釘：牙釘的幾何結構經研究證實會大幅地影響骨整合與骨癒合。然而，尋找一個具最佳幾何結構的牙釘是十分費時的。因此，本論文提出一套結合深度學習網路、細胞分化理論、隨機森林演算法與基因演算法的牙釘結構最佳化設計系統。其能夠在2.5秒內預測牙釘周圍的細胞分化情形，並基於螺紋間骨釘和骨頭的接觸長度以及骨頭長入的面積比來最佳化骨釘的骨癒合能力。經過基因演算法的多次迭代後，研究成功取得具優秀骨整合效率的最佳化牙釘，其結構的特色主要為牙釘中上段部分不具有明顯的螺紋結構。(2) 水膠：由於高生物相容性

、與天然細胞相似的材料性質，使得合成水膠被大量應用於組織工程中。但是水膠基板的外觀設計與受到之力學刺激會對其內部細胞的遷移行為有極大的影響，這使得水膠基板的細胞行為研究就顯得格外重要。本論文藉由有限元素軟體Abaqus探討水膠的拉伸應力、應變，以及觀察水膠局部區域的細胞移動行為。前者的研究成功呈現與實驗水膠基板相同的形變過程，並發現細胞的移動行為與水膠的應力分布有關。而後者的研究則利用Abaqus中的光滑粒子流體動力學模型，成功展現水膠中不同區域的細胞會有不同移動與聚散行為的現象。