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A Button a Day: All Buttons Great and Small

為了解決Technologies的問題，作者Godoroja, Lucy 這樣論述：

Full of quirky images and insightful stories, A Button a Day is an exploration of the craftsmanship and peculiar history of buttons. From being regulated by law to revolutionized by emerging technologies, these seemingly simple objects have a complex story.

Technologies進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Technologies的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Ceramic Masterpieces: Art, Structure and Technology

為了解決Technologies的問題，作者Vandiver, Pamela B./ Kingery, W. David 這樣論述：

Ceramic Masterpieces: Art, Structure andTechnology was first published by the Free Press in 1986. It won a publisher's award for art (American Publishers' Association, Scholarly and Technical, Honorable Mention, 1986). The copyright is held by David Kingery's son, William D. Kingery, Jr., who ab

out 11 years ago signed over to the American Ceramic Society the rights to publish a second edition of the book. This second edition is divided into four parts. In the introductory section, it states: "The appearance of a ceramic is determined by its internal structure, which is in turn determined b

y the technology of its manufacture. Revolutionary new methods of study and analysis have advanced out understanding of ceramics. This book applies these new methods, connecting visual impact, internal structure, and technology for a deeper appreciation of ceramic masterpieces." Each chapter outline

s the transformative art and structure of a ceramic material by providing a general outline of history, artistic value, antecedent technologies, manufacture of the particular dated example, analysis of macrostructure, then microstructure, then composition, then firing, variability and its relation t

o appearance, and finally significance of technology and its contribution to art and culture. In the ceramic technology section, the sequences and variability of processing, exemplified in the case studies, is inventoried with emphasis on structure and transformation.

會員制無人商店的精準行銷之研究

為了解決Technologies的問題，作者陳建仁 這樣論述：

科技的進步，並且網路的發展日漸與生活結合在一起，再加上行動裝置的普及等條件，促使人們在消費行為已陸續的將以往在實體營業據點且高度仰賴現金的模式開始移轉到無實體或無接觸的消費場域。2020起COVID-19疫情的肆虐下更加速改變人們的消費習慣，從禁止外出到能不外出就不外出，避免遭受疫情的感染，人們以減少對陌生人接觸的原則改變了原有的生活模式。因此推動了網路電商的第二次發展再起、以及外送平台的竄出。透過無實體或零接觸方式的消費比重在未來的消費比重可望持續提升，店家除了要把產品上架在上述通路外已是必然，但上架只是增加銷售的曝光度，真正的重點是如何主動出擊?讓消費者前來進行銷費。會員制的消費規則建立

目的起初除是為了能有較為穩定的會員消費者，如今可透過蒐集會員的消費紀錄，累積成有用的大數據，提供店家進行大數據的分析，讓其能夠善用執行行銷時的主要指引。透過分析資料，了解顧客的消費喜好、消費頻率、消費習慣，用於商家在進行行銷策略的主軸，以發現潛在的目標客戶，主動的提供/發送行銷資訊，將更有效率的達到提升營收的目的，以及避免過多無效的行銷成本的投放，減降營業費用以達到企業經營獲利目標。