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Interrelatedness in Chinese Religious Traditions: An Intercultural Philosophy

為了解決Diana的問題，作者Arghirescu, Diana 這樣論述：

Diana Arghirescu is Lecturer in the Department of Philosophy and Research Director of the Observatoire de l’Asie de l’Est at the University of Québec at Montreal, Canada.

Diana進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Diana的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Keto Meal Prep Cookbook For Beginners - Quick and Easy Ketogenic Cooking: The Fast Track to Epic Health and Wellness Living

為了解決Diana的問題，作者Watson, Diana 這樣論述：

跑步運動介入對國小高年級學童運動參與程度與身體自我概念之研究

為了解決Diana的問題，作者呂孟怡 這樣論述：

　　本研究目的在探討跑步運動介入對國小高年級學童運動參與程度與身體自我概念之影響。方法：以準實驗研究法，採前、後測，採立意取樣選取臺南市官田區某國小高年級四個班級為研究對象，分為實驗組和控制組：實驗組(男生17人，女生16人。平均年齡11歲，平均身高143.2公分，平均體重40.6公斤)，進行八週跑步運動課程，每週3次、每次30分鐘，於晨間活動實施；控制組(男生22人，女生11人。平均年齡12歲，平均身高149.2公分，平均體重47.3公斤)，則不實施任何運動訓練，採靜態晨間閱讀活動，合計66人。實驗組及控制組分別在實驗前、後接受運動參與程度與身體自我概念量表的前測及後測，以不同組別(實驗組

與控制組)及測驗別(前測與後測)為自變項，各量表之得分為依變項，研究採混合設計二因子變異數(Mixed design two-way ANOVA)分析進行考驗；若交互作用顯著差異，則進行單純主要效果(Simple main effect)考驗，以驗證其差異性，統計顯著訂為α=.05。結果：一、跑步運動介入後，實驗組的運動參與程度優於控制組。二、跑步運動入後，實驗組的身體自我概念優於控制組，除了外表構面外。三、跑步運動介入後，身體自我概念的五個構面，實驗組前、後測達顯著差異。四、控制組未接受跑步運動介入，在運動參與程度與身體自我概念方面，其前、後測皆無顯著差異。結論：一、跑步運動介入對國小學童的

運動參與程度有正面助益。二、跑步運動介入對國小學童身體自我概念(外表除外)有正面助益。